(E)-N'-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis
| العنوان: | (E)-N'-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis |
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| المؤلفون: | Feriani, Anouar, Khdhiri, Emna, Tir, Meriam, Elmufti, Afoua, Tlili, Nizar, Hajji, Raouf, Ammar, Houcine, Allouche, Noureddine, Abid, Souhir, Ghazouani, Lakhdar, Mnafgui, Kais |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2020 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Inflammation, Male, Article Subject, QH573-671, Molecular Structure, Myocardium, Anti-Inflammatory Agents, Hydrazones, Isoproterenol, Myocardial Infarction, Apoptosis, Rats, Oxidative Stress, Treatment Outcome, Coumarins, Animals, Benzopyrans, Rats, Wistar, Cytology, Biomarkers, Research Article |
| الوصف: | The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities. |
| وصف الملف: | text/xhtml |
| تدمد: | 1942-0994 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::25f0d79aa9591bf89eb5e219cdfee83dTest https://pubmed.ncbi.nlm.nih.gov/32215169Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....25f0d79aa9591bf89eb5e219cdfee83d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 |
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