دورية أكاديمية
Chemotherapeutics Targeting Immune Activation by Staphylococcal Superantigens
| العنوان: | Chemotherapeutics Targeting Immune Activation by Staphylococcal Superantigens |
|---|---|
| المؤلفون: | Krakauer, Teresa |
| المساهمون: | ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD |
| المصدر: | DTIC AND NTIS |
| سنة النشر: | 2005 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Biochemistry, Pharmacology, Microbiology, ENTEROTOXINS, IMMUNITY, ANTIGENS, STAPHYLOCOCCUS, CHEMOTHERAPEUTIC AGENTS, IN VITRO ANALYSIS, MONOCYTES, FOOD POISONING, CYTOKINES, SHOCK(PATHOLOGY), MACROPHAGES, RECEPTOR SITES(PHYSIOLOGY), CELLS(BIOLOGY), IN VIVO ANALYSIS, T LYMPHOCYTES, SEB(STAPHYLOCOCCAL ENTEROTOXIN B), TCR(T CELL RECEPTORS), STAPHYLOCOCCAL SUPERANTIGENS, TOXIC SHOCK |
| الوصف: | Staphylococcal enterotoxin B (SEB) and related superantigenic toxins are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to toxic shock. These toxins bind to both MHC class II molecules and specific V-beta regions of T cell receptors (TCR), resulting in the activation of both monocytes/macrophages and T lymphocytes. The interactions of these toxins with host cells lead to excessive production of proinflammatory cytokines and T cell proliferation, causing clinical symptoms that include fever, hypotension and shock. Different domains of SEB contributing to MHC class II or TCR interactions have been mapped and defined by mutagenesis, crystallography and other biochemical techniques. This review summarizes the in vitro and in vivo effects of staphylococcal superantigens, and the therapeutic agents to mitigate their toxic effects. Potential targets to prevent the toxic effects of bacterial superantigens include blocking the interaction of SEs with MHC or TCR, or other costimulatory molecules; inhibition of signal transduction pathways used by these superantigens; inhibition of cytokine and chemokine production; and inhibition of the downstream signaling pathways used by proinflammatory cytokines and chemokines. Early blockade of these targets proves to be useful in vitro and in vivo testing of therapeutics against SEB-induced toxic shock will also be reviewed. ; Pub. in Medical Science Monitor, v11 n9 pRA290-295, 2005. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://www.dtic.mil/docs/citations/ADA440214Test |
| الإتاحة: | http://www.dtic.mil/docs/citations/ADA440214Test http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA440214Test |
| حقوق: | Approved for public release; distribution is unlimited. This document is not available from DTIC in microfiche. |
| رقم الانضمام: | edsbas.9B4E76B3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |