التفاصيل البيبلوغرافية
| العنوان: |
GST AND MDR1 GENE POLYMORPHISMS IN CHRONIC MYELOID LEUKEMIC PATIENTS. |
| المؤلفون: |
Tripathi, Tanya1 tanyatripathi@rediffmail.com, Mehdi, Syed Riaz1, Srivastava, A. N.1 |
| المصدر: |
Era's Journal of Medical Research. Jul-Dec2019, Vol. 6 Issue 2, p89-93. 5p. |
| مصطلحات موضوعية: |
*GENETIC polymorphisms, *CHRONIC myeloid leukemia, *CYTOCHROME P-450, *CARCINOGENS |
| مستخلص: |
Chronic myeloid leukemia is a myeloproliferative neoplasm characterized by Philadelphia chromosome showing translocation 9:22(q34;q11). Many exogenous and endogenous substances lead to genetic alterations and result in development of cancer including chronic myeloid leukemia. Metabolizing Enzymes (phase1, 2 and 3) offer the first line of defense but multiple polymorphisms seen in these affect the ability of these enzymes to metabolize the carcinogens thereby increasing the individual's chance of suffering from cancer. Major gene polymorphisms are seen in Glutathione- S-Transferase family, Multi Drug Resistance Gene, Cytochrome P450 family, and recently reported Natural Killer Group Receptors Gene Polymorphism in Chronic myeloid leukemia. These gene polymorphisms also have been seen to affect individual's response to therapy. Hence it has now become essential to study this phenomenon of gene polymorphisms as it will show light on the fact as to how some individuals are more susceptible to develop cancer and why every individual has difference response to therapy in CML. This prospective will help in the treatment and follow up of these patients and give a broader picture of importance of these polymorphism in cancers like Chronic myeloid leukemia. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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