التفاصيل البيبلوغرافية
| العنوان: |
Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation. |
| المؤلفون: |
Oberbauer, Rainer, Segoloni, Giuseppe, Campistol, Josep M., Kreis, Henri, Mota, Alfredo, Lawen, Joseph, Russ, Graeme, Grinyó, Josep M., Stallone, Giovanni, Hartmann, Anders, Pinto, Jose R., Chapman, Jeremy, Burke, James T., Brault, Yves, Neylan, John F. |
| المصدر: |
Transplant International; Jan2005, Vol. 18 Issue 1, p22-28, 7p |
| مصطلحات موضوعية: |
CYCLOSPORINE, IMMUNOSUPPRESSIVE agents, CYCLIC peptides, BIOPSY, RAPAMYCIN, THERAPEUTICS |
| مستخلص: |
We report the 48-month results of a trial testing whether withdrawal of cyclosporine (CsA) from a sirolimus (SRL)-CsA-steroid (ST) regimen would impact renal allograft survival. Eligible patients receiving SRL-CsA-ST from transplantation were randomly assigned at 3 months to remain on triple therapy (SRL-CsA-ST, n = 215) or to have CsA withdrawn and SRL trough concentrations increased (SRL-ST, n = 215). SRL-ST therapy resulted in significantly better graft survival, either when including death with a functioning graft as an event (84.2% vs. 91.5%, P = 0.024) or when censoring it (90.6% vs. 96.1%, P = 0.026). Calculated glomerular filtration rate (43.8 vs. 58.3 ml/min, P < 0.001) and mean arterial blood pressure (101.3 vs. 97.1 mmHg, P = 0.047) were also improved with SRL-ST. Differences in the incidences of biopsy-proven acute rejection after randomization (6.5% vs. 10.2%, SRL-CsA-ST versus SRL-ST, respectively) and mortality (7.9% vs. 4.7%) were not significant. SRL-CsA-ST-treated patients had significantly higher incidences of adverse events generally associated with CsA, whereas those in the SRL-ST group experienced greater frequencies of events commonly related to higher trough levels of SRL. In conclusion, early withdrawal of CsA from a SRL-CsA-ST regimen rapidly improves renal function and ultimately results in better graft survival. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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