التفاصيل البيبلوغرافية
| العنوان: |
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer |
| المؤلفون: |
Nagalingam R. Sundaresan, Mei Ming, Yu-Ying He, Mahesh P. Gupta, Chu-Xia Deng, Weinong Han, Baozhong Zhao |
| المصدر: |
Cancer research. 74(20) |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
SIRT6, Cancer Research, Skin Neoplasms, Carcinogenesis, Cell Survival, Ultraviolet Rays, RNA Stability, Gene Expression, Human skin, Biology, medicine.disease_cause, Article, medicine, Animals, Humans, Sirtuins, PI3K/AKT/mTOR pathway, Cells, Cultured, Cell Proliferation, Microbiology & Cell Biology, Mice, Knockout, Epidermis (botany), Oncogene, integumentary system, Adenylate Kinase, Cancer, Oncogenes, medicine.disease, Cell biology, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Oncology, Cyclooxygenase 2, Enzyme Induction, Cancer research, Carcinoma, Squamous Cell, Skin cancer, Epidermis, Proto-Oncogene Proteins c-akt |
| الوصف: |
SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis. SIRT6 promoted expression of COX-2 by repressing AMPK signaling, thereby increasing cell proliferation and survival in the skin epidermis. SIRT6 expression in skin keratinocytes was increased by exposure to UVB light through activation of the AKT pathway. Clinically, we found that SIRT6 was upregulated in human skin squamous cell carcinoma. Taken together, our results provide evidence that SIRT6 functions as an oncogene in the epidermis and suggest greater complexity to its role in epithelial carcinogenesis. Cancer Res; 74(20); 5925–33. ©2014 AACR. |
| وصف الملف: |
application/pdf |
| تدمد: |
1538-7445 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceccd1476fd7b9d6d4b9a2fe8fa794aTest
https://pubmed.ncbi.nlm.nih.gov/25320180Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....1ceccd1476fd7b9d6d4b9a2fe8fa794a |
| قاعدة البيانات: |
OpenAIRE |
