التفاصيل البيبلوغرافية
| العنوان: |
Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. |
| المؤلفون: |
Sánchez-Alcázar, J. A., Bradbury, D. A., Brea-Calvo, G., Navas, P., Knox, A. J. |
| المصدر: |
Apoptosis; Dec2003, Vol. 8 Issue 6, p639-647, 9p |
| مصطلحات موضوعية: |
APOPTOSIS, CAMPTOTHECIN, LUNG cancer, CYCLOOXYGENASES, CELL lines |
| مستخلص: |
Recent observations show a positive correlation between the expression of cyclooxygenase (COX), especially COX-2), and cancer development. Here we tested the hypothesis that expression of COX-2 could influence apoptosis in lung cancer cell lines. To address this question, we determined the effects of camptothecin-induced apoptosis on three lung cancer cell lines which over express COX-1 (CORL23), COX-2 (MOR-P) and neither isoform (H-460), and determine if these effects were prostaglandin mediated. We also compared the effects of non-selective and isoenzyme selective COX-2 inhibitors on camptothecin-induced apoptosis in these three cell lines. Camptothecin induced apoptosis in all three cell lines independently of COX-1 or COX-2 expression. Indomethacin, a non-selective COX inhibitor and NS398, a selective COX-2 inhibitor had no effect on camptothecin-induced apoptosis at concentrations that abolished prostaglandin production. In conclusion, these finding suggest that the COX pathway is not involved in camptothecin-induced apoptosis of non-small cell lung cancer cell lines. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
