المؤلفون: Xu, Qianyi^1,2 (AUTHOR) Qianyi.Xu@jefferson.edu, Vinogradskiy, Yevgeniy² (AUTHOR), Grimm, Jimm³ (AUTHOR), Nie, Wei¹ (AUTHOR), Dupre, Pamela¹ (AUTHOR), Chawla, Ashish K¹ (AUTHOR), Bajaj, Gopal¹ (AUTHOR), Yang, Haihua⁴ (AUTHOR), LaCouture, Tamara² (AUTHOR), Fan, Jiajin¹ (AUTHOR)

المصدر: British Journal of Radiology. Mar2024, Vol. 97 Issue 1155, p660-667. 8p.

مصطلحات موضوعية: *STEREOTACTIC radiotherapy, *STEREOTACTIC radiosurgery, *QUALITY assurance, *SURGICAL robots, *ROBOTICS, *TRACKING radar

مستخلص: Objectives To evaluate patient-specific quality assurance (PSQA) of 3 targets in a single delivery using a novel film-based phantom. Methods The phantom was designed to rotate freely as a sphere and could measure 3 targets with film in a single delivery. After identifying the coordinates of 3 targets in the skull, the rotation angles about the equator and meridian were computed for optimal phantom setup, ensuring the film plane intersected the 3 targets. The plans were delivered on the CyberKnife system using fiducial tracking. The irradiated films were scanned and processed. All films were analysed using 3 gamma criteria. Results Fifteen CyberKnife test plans with 3 different modalities were delivered on the phantom. Both automatic and marker-based registration methods were applied when registering the irradiated film and dose plane. Gamma analysis was performed using a 3%/1 mm, 2%/1 mm, and 1%/1 mm criteria with a 10% threshold. For the automatic registration method, the passing rates were 98.2% ± 1.9%, 94.2% ± 3.7%, and 80.9% ± 6.3%, respectively. For the marker-based registration approach, the passing rates were 96.4% ± 2.7%, 91.7% ± 4.3%, and 78.4% ± 6.2%, respectively. Conclusions A novel spherical phantom was evaluated for the CyberKnife system and achieved acceptable PSQA passing rates using TG218 recommendations. The phantom can measure true-composite dose and offers high-resolution results for PSQA, making it a valuable device for robotic radiosurgery. Advances in knowledge This is the first study on PSQA of 3 targets concurrently on the CyberKnife system. [ABSTRACT FROM AUTHOR]

المؤلفون: Khaledi, Navid, Khan, Rao, Gräfe, James L.

المصدر: Journal of Medical Physics; Oct-Dec2023, Vol. 48 Issue 4, p312-327, 16p

مصطلحات موضوعية: STEREOTAXIC techniques, STEREOTACTIC radiotherapy, RADIOTHERAPY safety, STEREOTACTIC radiosurgery, TECHNOLOGICAL innovations, BRAIN damage

مستخلص: Radiosurgery and stereotactic radiotherapy have established themselves as precise and accurate areas of radiation oncology for the treatment of brain and extracranial lesions. Along with the evolution of other methods of radiotherapy, this type of treatment has been associated with significant advances in terms of a variety of modalities and techniques to improve the accuracy and efficacy of treatment. This paper provides a comprehensive overview of the progress in stereotactic radiosurgery (SRS) over several decades, and includes a review of various articles and research papers, commencing with the emergence of stereotactic techniques in radiotherapy. Key clinical aspects of SRS, such as fixation methods, radiobiology considerations, quality assurance practices, and treatment planning strategies, are presented. In addition, the review highlights the technological advancements in treatment modalities, encompassing the transition from cobalt-based systems to linear accelerator-based modalities. By addressing these topics, this study aims to offer insights into the advancements that have shaped the field of SRS, that have ultimately enhanced the accuracy and effectiveness of treatment. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Medical Physics is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Navid Khaledi, Rao Khan, James L Gräfe

المصدر: Journal of Medical Physics, Vol 48, Iss 4, Pp 312-327 (2023)

مصطلحات موضوعية: artificial intelligence, cyberknife, gamma knife, history, radiosurgery, stereotactic body radiation therapy, stereotactic radiosurgery, stereotactic radiotherapy, zap-x, radiotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Radiosurgery and stereotactic radiotherapy have established themselves as precise and accurate areas of radiation oncology for the treatment of brain and extracranial lesions. Along with the evolution of other methods of radiotherapy, this type of treatment has been associated with significant advances in terms of a variety of modalities and techniques to improve the accuracy and efficacy of treatment. This paper provides a comprehensive overview of the progress in stereotactic radiosurgery (SRS) over several decades, and includes a review of various articles and research papers, commencing with the emergence of stereotactic techniques in radiotherapy. Key clinical aspects of SRS, such as fixation methods, radiobiology considerations, quality assurance practices, and treatment planning strategies, are presented. In addition, the review highlights the technological advancements in treatment modalities, encompassing the transition from cobalt-based systems to linear accelerator-based modalities. By addressing these topics, this study aims to offer insights into the advancements that have shaped the field of SRS, that have ultimately enhanced the accuracy and effectiveness of treatment.

وصف الملف: electronic resource

العلاقة: http://www.jmp.org.in/article.asp?issn=0971-6203;year=2023;volume=48;issue=4;spage=312;epage=327;aulast=KhalediTest; https://doaj.org/toc/0971-6203Test; https://doaj.org/toc/1998-3913Test

الوصول الحر: https://doaj.org/article/3a4cb09a6af545d9bd3a2e7c0c400a47Test

المؤلفون: Kalinauskaite, Goda G.^1,2 (AUTHOR) goda.kalinauskaite@charite.de, Tinhofer, Ingeborg I.^1,3 (AUTHOR), Kufeld, Markus M.² (AUTHOR), Kluge, Anne A.^1,2 (AUTHOR), Grün, Arne A.^1,2 (AUTHOR), Budach, Volker V.^1,2 (AUTHOR), Senger, Carolin C.^1,2 (AUTHOR), Stromberger, Carmen C.^1,2 (AUTHOR)

المصدر: BMC Cancer. 5/11/2020, Vol. 20 Issue 1, p1-10. 10p. 1 Color Photograph, 7 Charts, 1 Graph.

مصطلحات موضوعية: *STEREOTACTIC radiotherapy, *STEREOTACTIC radiosurgery, *KARNOFSKY Performance Status, *LUNGS, *LUNG surgery

مستخلص: Background: Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved to be as effective and safe as surgery in treating lung metastases (LM). However, it is not clear which patients benefit most and what are the most suitable fractionation regimens. The aim of this study was to analyze treatment outcomes after single fraction radiosurgery (SFRS) and fractionated SBRT (fSBRT) in patients with lung oligometastases and identify prognostic clinical features for better survival outcomes.Methods: Fifty-two patients with 94 LM treated with SFRS or fSBRT between 2010 and 2016 were analyzed. The characteristics of primary tumor, LM, treatment, toxicity profiles and outcomes were assessed. Kaplan-Meier and Cox regression analyses were used for estimation of local control (LC), overall survival (OS) and progression-free survival.Results: Ninety-four LM in 52 patients were treated using SFRS/fSBRT with a median of 2 lesions per patient (range: 1-5). The median planning target volume (PTV)-encompassing dose for SFRS was 24 Gy (range: 17-26) compared to 45 Gy (range: 20-60) in 2-12 fractions with fSBRT. The median follow-up time was 21 months (range: 3-68). LC rates at 1 and 2 years for SFSR vs. fSBRT were 89 and 83% vs. 75 and 59%, respectively (p = 0.026). LM treated with SFSR were significantly smaller (p = 0.001). The 1 and 2-year OS rates for all patients were 84 and 71%, respectively. In univariate analysis treatment with SFRS, an interval of ≥12 months between diagnosis of LM and treatment, non-colorectal cancer histology and BED < 100 Gy were significantly associated with better LC. However, none of these parameters remained significant in the multivariate Cox regression model. OS was significantly better in patients with negative lymph nodes (N0), Karnofsky performance status (KPS) > 70% and time to first metastasis ≥12 months. There was no grade 3 acute or late toxicity.Conclusions: Longer time to first metastasis, good KPS and N0 predicted better OS. Good LC and low toxicity rates were achieved after short SBRT schedules. [ABSTRACT FROM AUTHOR]

المؤلفون: Xu, Qianyi, Huynh, Kiet, Nie, Wei, Rose, Mark S., Chawla, Ashish K., Choe, Kevin S., Kanani, Samir, Kubicek, Gregory J., Fan, Jiajin

المصدر: Journal of Applied Clinical Medical Physics; May2022, Vol. 23 Issue 5, p1-8, 8p

مصطلحات موضوعية: STEREOTACTIC radiosurgery, QUALITY assurance, DIODES, TRIGEMINAL neuralgia, STEREOTACTIC radiotherapy, CEREBRAL arteriovenous malformations, STEREOTAXIC techniques

مستخلص: The purpose of the study was to introduce and evaluate a high‐resolution diode array for patient‐specific quality assurance (PSQA) of CyberKnife brain stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT). Thirty‐three intracranial plans were retrospectively delivered on the SRS MapCHECK using fixed cone, Iris, and multileaf collimator (MLC). The plans were selected to cover a range of sites from large tumor bed, single/multiple small brain metastases (METs) to trigeminal neuralgia. Fiducial tracking using the four fiducials embedded around the detector plane was used as image guidance. Results were analyzed before and after registration based on absolute dose gamma criterion of 1 mm distance‐to‐agreement and 0.5%–3% dose‐difference. Overall, the gamma passing rates (1 mm and 3% criterion) before registration for all the patients were above 90% for all three treatment modalities (96.8 ± 3.5%, the lowest passing rate of 90.4%), and were improved after registration (99.3 ± 1.5%). When tighter criteria (1 mm and 2%) were applied, the gamma passing rates after registration for all the cases dropped to 97.3 ± 3.2%. For trigeminal neuralgia cases, we applied 1 mm and 0.5% criterion and the passing rates dropped from 100 ± 0.0% to 98.5 ± 2.0%. The mean delivery time was 33.4 ± 11.7 min, 24.0 ± 4.9 min, and 17.1 ± 2.6 min for the fixed cone, Iris, and MLC, respectively. With superior gamma passing rates and reasonable quality assurance (QA) time, we believe the SRS MapCHECK could be a good option for routine PSQA for CyberKnife SRS/SRT. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Applied Clinical Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Xiaojie Liu¹, Yongchun Song¹, Ping Liang², Tingshi Su^2,3, Huojun Zhang⁴, Xianzhi Zhao⁴, Zhiyong Yuan¹, Ping Wang¹ wangping@tjmuch.com

المصدر: OncoTargets & Therapy. Nov2017, Vol. 10, p5289-5295. 7p. 5 Charts, 1 Graph.

مصطلحات موضوعية: *STEREOTACTIC radiosurgery, *STEREOTACTIC radiotherapy, *RADIOTHERAPY, *LIVER cancer patients, *LIVER cancer

مستخلص: Objective: The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors.Methods: A total of 74 HCC patients with Child–Turcotte–Pugh (CTP) Class A were included in a multi-institutional, single-arm Phase II trial (NCT 02363218) between February 2013 and August 2016. All patients received SBRT treatment at a dose of 45 Gy/3f. The liver function was compared before and after SBRT treatment by the analysis of adverse hepatic reactions and changes in CTP classification.Results: After SBRT treatment, eight patients presented with decreases in CTP classification and 13 patients presented with ≥ grade 2 hepatic adverse reactions. For patients presenting with ≥ grade 2 hepatic adverse reactions, the total liver volume of ≤1,162 mL and a normal liver volume (total liver volume – gross tumor volume [GTV]) of ≤1,148 mL were found to be independent risk factors and statistically significant (P<0.05). Conclusion: The total liver volume and normal liver volume are associated with the occurrence of ≥ grade 2 hepatic adverse reactions after SBRT treatment on HCC patients. Therefore, if the fractionated scheme of 45 Gy/3f is applied in SBRT for HCC patients, a total liver volume >1,162 mL and a normal liver volume >1,148 mL should be ensured to improve therapeutic safety. [ABSTRACT FROM AUTHOR]

المؤلفون: Yu, Suhong, Xu, Huijun, Zhang, Yin, Zhang, Xin, Dyer, Michael A., Hirsch, Ariel E., Tam Truong, Minh, Zhen, Heming

المساهمون: Department of Radiation Oncology

المصدر: Journal of applied clinical medical physics ; 22 ; 3 ; 48-54

مصطلحات موضوعية: Cyberknife, knowledge-based planning, stereotactic radiosurgery, stereotactic radiotherapy, Artificial Intelligence and Robotics, Physics, Radiation Medicine

الوصف: PURPOSE: To develop a knowledge-based planning (KBP) model that predicts dosimetric indices and facilitates planning in CyberKnife intracranial stereotactic radiosurgery/radiotherapy (SRS/SRT). METHODS: Forty CyberKnife SRS/SRT plans were retrospectively used to build a linear KBP model which correlated the equivalent radius of the PTV (req_PTV ) and the equivalent radius of volume that receives a set of prescription dose (req_Vi , where Vi = V10% , V20% . V120% ). To evaluate the model's predictability, a fourfold cross-validation was performed for dosimetric indices such as gradient measure (GM) and brain V50% . The accuracy of the prediction was quantified by the mean and the standard deviation of the difference between planned and predicted values, (i.e., DeltaGM = GMpred - GMclin and fractional DeltaV50% = (V50%pred - V50%clin )/V50%clin ) and a coefficient of determination, R(2) . Then, the KBP model was incorporated into the planning for another 22 clinical cases. The training plans and the KBP test plans were compared in terms of the new conformity index (nCI) as well as the planning efficiency. RESULTS: Our KBP model showed desirable predictability. For the 40 training plans, the average prediction error from cross-validation was only 0.36 +/- 0.06 mm for DeltaGM, and 0.12 +/- 0.08 for DeltaV50% . The R(2) for the linear fit between req_PTV and req_vi was 0.985 +/- 0.019 for isodose volumes ranging from V10% to V120% ; particularly, R(2) = 0.995 for V50% and R(2) = 0.997 for V100% . Compared to the training plans, our KBP test plan nCI was improved from 1.31 +/- 0.15 to 1.15 +/- 0.08 (P < 0.0001). The efficient automatic generation of the optimization constraints by using our model requested no or little planner's intervention. CONCLUSION: We demonstrated a linear KBP based on PTV volumes that accurately predicts CyberKnife SRS/SRT planning dosimetric indices and greatly helps achieve superior plan quality and planning efficiency.

العلاقة: Link to Article in PubMed; Yu S, Xu H, Zhang Y, Zhang X, Dyer MA, Hirsch AE, Tam Truong M, Zhen H. Knowledge-based planning in robotic intracranial stereotactic radiosurgery treatments. J Appl Clin Med Phys. 2021 Mar;22(3):48-54. doi:10.1002/acm2.13173. Epub 2021 Feb 9. PMID: 33560592; PMCID: PMC7984472. Link to article on publisher's site; 1526-9914 (Linking); http://hdl.handle.net/20.500.14038/41802Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5635&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4604Test; oapubs/4604

الإتاحة: https://doi.org/10.1002/acm2.13173Test
https://doi.org/20.500.14038/41802Test
https://hdl.handle.net/20.500.14038/41802Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5635&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/4604Test

المؤلفون: Felix Ehret, David Kaul, Volker Budach, Laura-Nanna Lohkamp

المصدر: Cancers; Volume 14; Issue 4; Pages: 1085

مصطلحات موضوعية: pediatric neuro-oncology, neuro-oncology, systematic review, PRISMA, stereotactic radiosurgery, stereotactic radiotherapy, robotic radiosurgery, CyberKnife

الوصف: Background: CyberKnife-based robotic radiosurgery (RRS) is a widely used treatment modality for various benign and malignant tumors of the central nervous system (CNS) in adults due to its high precision, favorable safety profile, and efficacy. Although RRS is emerging in pediatric neuro-oncology, scientific evidence for treatment indications, treatment parameters, and patient outcomes is scarce. This systematic review summarizes the current experience and evidence for RRS and robotic stereotactic radiotherapy (RSRT) in pediatric neuro-oncology. Methods: We performed a systematic review based on the databases Ovid Medline, Embase, Cochrane Library, and PubMed to identify studies and published articles reporting on RRS and RSRT treatments in pediatric neuro-oncology. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied herein. Articles were included if they described the application of RRS and RSRT in pediatric neuro-oncological patients. The quality of the articles was assessed based on their evidence level and their risk for bias using the original as well as an adapted version of the Newcastle Ottawa Quality Assessment Scale (NOS). Only articles published until 1 August 2021, were included. Results: A total of 23 articles were included after final review and removal of duplicates. Articles reported on a broad variety of CNS entities with various treatment indications. A majority of publications lacked substantial sample sizes and a prospective study design. Several reports included adult patients, thereby limiting the possibility of data extraction and analysis of pediatric patients. RRS and RSRT were mostly used in the setting of adjuvant, palliative, and salvage treatments with decent local control rates and acceptable short-to-intermediate-term toxicity. However, follow-up durations were limited. The evidence level was IV for all studies; the NOS score ranged between four and six, while the overall risk of bias was moderate to low. Conclusion: Publications ...

وصف الملف: application/pdf

العلاقة: Cancer Therapy; https://dx.doi.org/10.3390/cancers14041085Test

الإتاحة: https://doi.org/10.3390/cancers14041085Test

المؤلفون: Ehret, Felix, Kaul, David, Budach, Volker, Lohkamp, Laura-Nanna

مصطلحات موضوعية: pediatric neuro-oncology, neuro-oncology, systematic review, PRISMA, stereotactic radiosurgery, stereotactic radiotherapy, robotic radiosurgery, CyberKnife, ddc:610

الوصف: Background: CyberKnife-based robotic radiosurgery (RRS) is a widely used treatment modality for various benign and malignant tumors of the central nervous system (CNS) in adults due to its high precision, favorable safety profile, and efficacy. Although RRS is emerging in pediatric neuro-oncology, scientific evidence for treatment indications, treatment parameters, and patient outcomes is scarce. This systematic review summarizes the current experience and evidence for RRS and robotic stereotactic radiotherapy (RSRT) in pediatric neuro-oncology. Methods: We performed a systematic review based on the databases Ovid Medline, Embase, Cochrane Library, and PubMed to identify studies and published articles reporting on RRS and RSRT treatments in pediatric neuro-oncology. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied herein. Articles were included if they described the application of RRS and RSRT in pediatric neuro-oncological patients. The quality of the articles was assessed based on their evidence level and their risk for bias using the original as well as an adapted version of the Newcastle Ottawa Quality Assessment Scale (NOS). Only articles published until 1 August 2021, were included. Results: A total of 23 articles were included after final review and removal of duplicates. Articles reported on a broad variety of CNS entities with various treatment indications. A majority of publications lacked substantial sample sizes and a prospective study design. Several reports included adult patients, thereby limiting the possibility of data extraction and analysis of pediatric patients. RRS and RSRT were mostly used in the setting of adjuvant, palliative, and salvage treatments with decent local control rates and acceptable short-to-intermediate-term toxicity. However, follow-up durations were limited. The evidence level was IV for all studies; the NOS score ranged between four and six, while the overall risk of bias was moderate to low. Conclusion: Publications ...

وصف الملف: application/pdf

العلاقة: https://refubium.fu-berlin.de/handle/fub188/36152Test; http://dx.doi.org/10.17169/refubium-35868Test

الإتاحة: https://doi.org/10.17169/refubium-35868Test
https://doi.org/10.3390/cancers14041085Test
https://refubium.fu-berlin.de/handle/fub188/36152Test

المؤلفون: Yu, Suhong, Xu, Huijun, Zhang, Yin, Zhang, Xin, Dyer, Michael A., Hirsch, Ariel E., Tam Truong, Minh, Zhen, Heming

المصدر: Journal of Applied Clinical Medical Physics; Mar2021, Vol. 22 Issue 3, p48-54, 7p

مصطلحات موضوعية: STEREOTACTIC radiosurgery, STEREOTAXIC techniques, STEREOTACTIC radiotherapy, STANDARD deviations, ROBOTICS, CONFORMITY

مستخلص: Purpose: To develop a knowledge‐based planning (KBP) model that predicts dosimetric indices and facilitates planning in CyberKnife intracranial stereotactic radiosurgery/radiotherapy (SRS/SRT). Methods: Forty CyberKnife SRS/SRT plans were retrospectively used to build a linear KBP model which correlated the equivalent radius of the PTV (req_PTV) and the equivalent radius of volume that receives a set of prescription dose (req_Vi, where Vi = V10%, V20% ... V120%). To evaluate the model's predictability, a fourfold cross‐validation was performed for dosimetric indices such as gradient measure (GM) and brain V50%. The accuracy of the prediction was quantified by the mean and the standard deviation of the difference between planned and predicted values, (i.e., ΔGM = GMpred − GMclin and fractional ΔV50% = (V50%pred − V50%clin)/V50%clin) and a coefficient of determination, R2. Then, the KBP model was incorporated into the planning for another 22 clinical cases. The training plans and the KBP test plans were compared in terms of the new conformity index (nCI) as well as the planning efficiency. Results: Our KBP model showed desirable predictability. For the 40 training plans, the average prediction error from cross‐validation was only 0.36 ± 0.06 mm for ΔGM, and 0.12 ± 0.08 for ΔV50%. The R2 for the linear fit between req_PTV and req_vi was 0.985 ± 0.019 for isodose volumes ranging from V10% to V120%; particularly, R2 = 0.995 for V50% and R2 = 0.997 for V100%. Compared to the training plans, our KBP test plan nCI was improved from 1.31 ± 0.15 to 1.15 ± 0.08 (P < 0.0001). The efficient automatic generation of the optimization constraints by using our model requested no or little planner's intervention. Conclusion: We demonstrated a linear KBP based on PTV volumes that accurately predicts CyberKnife SRS/SRT planning dosimetric indices and greatly helps achieve superior plan quality and planning efficiency. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Applied Clinical Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)