دورية أكاديمية
Reinforcement Signaling of Punishment versus Relief in Fruit Flies
| العنوان: | Reinforcement Signaling of Punishment versus Relief in Fruit Flies |
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| اللغة: | English |
| المؤلفون: | König, Christian, Khalili, Afshin, Ganesan, Mathangi, Nishu, Amrita P., Garza, Alejandra P., Niewalda, Thomas, Gerber, Bertram, Aso, Yoshinori, Yarali, Ayse |
| المصدر: | Learning & Memory. Jun 2018 25(6):247-257. |
| الإتاحة: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.orgTest |
| تمت مراجعته من قبل الزملاء: | Y |
| Page Count: | 11 |
| تاريخ النشر: | 2018 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| الواصفات: | Negative Reinforcement, Conditioning, Entomology, Memory, Cues, Pain, Recall (Psychology), Olfactory Perception |
| DOI: | 10.1101/lm.047308.118 |
| تدمد: | 1072-0502 |
| مستخلص: | Painful events establish opponent memories: cues that precede pain are remembered negatively, whereas cues that follow pain, thus coinciding with relief are recalled positively. How do individual reinforcement-signaling neurons contribute to this "timing-dependent valence-reversal?" We addressed this question using an optogenetic approach in the fruit fly. Two types of fly dopaminergic neuron, each comprising just one paired cell, indeed established learned avoidance of odors that preceded their photostimulation during training, and learned approach to odors that followed the photostimulation. This is in striking parallel to punishment versus relief memories reinforced by a real noxious event. For only one of these neuron types, both effects were strong enough for further analyses. Notably, interfering with dopamine biosynthesis in these neurons partially impaired the punishing effect, but not the relieving after-effect of their photostimulation. We discuss how this finding constraints existing computational models of punishment versus relief memories and introduce a new model, which also incorporates findings from mammals. Furthermore, whether using dopaminergic neuron photostimulation or a real noxious event, more prolonged punishment led to stronger relief. This parametric feature of relief may also apply to other animals and may explain particular aspects of related behavioral dysfunction in humans. |
| Abstractor: | As Provided |
| Number of References: | 97 |
| Entry Date: | 2018 |
| رقم الانضمام: | EJ1180954 |
| قاعدة البيانات: | ERIC |
Full Text Finder | تدمد: | 1072-0502 |
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| DOI: | 10.1101/lm.047308.118 |