دورية أكاديمية
Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival
| العنوان: | Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival |
|---|---|
| المؤلفون: | Tobin, N. P., Harrell, J. C., Lövrot, J., Egyhazi Brage, S., Frostvik Stolt, M., Carlsson, L., Einbeigi, Z., Linderholm, B., Loman, N., Malmberg, M., Walz, T., Fernö, M., Perou, C. M., Bergh, J., Hatschek, T., Lindström, L. S. |
| المصدر: | Annals of Oncology, 26(1) |
| سنة النشر: | 2015 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Gene Regulatory Networks, E2F3, neoplasm metastasis, Confidence Intervals, Catenins, Genes, Phenobarbital, Gene Expression, Apoptosis, breast cancer, SRC, IGF1, Homo sapiens, CTNNB1, Recurrence, Estrogens, PTEN, neoplasms, Biopsy, Multicenter Studies as Topic, Breast Neoplasms, MYC, Biological Processes |
| الوصف: | An enhanced understanding of the biology of breast cancer metastases is needed to individualize patient management. Here, we show that tumor characteristics of breast cancer metastases significantly influence post-relapse survival, emphasizing that molecular investigation at relapse offers clinically relevant information, with the potential to improve patient management and survival.BackgroundWe and others have recently shown that tumor characteristics are altered throughout tumor progression. These findings emphasize the need for re-examination of tumor characteristics at relapse and have led to recommendations from ESMO and the Swedish Breast Cancer group. Here, we aim to determine whether tumor characteristics and molecular subtypes in breast cancer metastases confer clinically relevant prognostic information for patients.Patients and methodsThe translational aspect of the Swedish multicenter randomized trial called TEX included 111 patients with at least one biopsy from a morphologically confirmed locoregional or distant breast cancer metastasis diagnosed from December 2002 until June 2007. All patients had detailed clinical information, complete follow-up, and metastasis gene expression information (Affymetrix array GPL10379). We assessed the previously published gene expression modules describing biological processes [proliferation, apoptosis, human epidermal receptor 2 (HER2) and estrogen (ER) signaling, tumor invasion, immune response, and angiogenesis] and pathways (Ras, MAPK, PTEN, AKT-MTOR, PI3KCA, IGF1, Src, Myc, E2F3, and β-catenin) and the intrinsic subtypes (PAM50). Furthermore, by contrasting genes expressed in the metastases in relation to survival, we derived a poor metastasis survival signature.ResultsA significant reduction in post-relapse breast cancer-specific survival was associated with low-ER receptor signaling and apoptosis gene module scores, and high AKT-MTOR, Ras, and β-catenin module scores. Similarly, intrinsic subtyping of the metastases provided statistically significant ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/69ad-q951Test; https://cdr.lib.unc.edu/downloads/sb397f96r?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/sb397f96rTest |
| DOI: | 10.17615/69ad-q951 |
| الإتاحة: | https://doi.org/10.17615/69ad-q951Test https://cdr.lib.unc.edu/downloads/sb397f96r?file=thumbnailTest https://cdr.lib.unc.edu/downloads/sb397f96rTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.DC1AA1EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/69ad-q951 |
|---|