Long-term neuropsychological outcome following pediatric anti-NMDAR encephalitis
| العنوان: | Long-term neuropsychological outcome following pediatric anti-NMDAR encephalitis |
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| المؤلفون: | Bruijn, M.A. de, Aarsen, F.K., Oosterhout, M.P., Knoop, M.M. van der, Catsman-Berrevoets, C.E., Schreurs, M.W., Bastiaansen, D.E.M., Sillevis Smitt, P.A., Haaxma, C.A., Neuteboom, R.F., Titulaer, M.J. |
| المساهمون: | Neurology, Child and Adolescent Psychiatry / Psychology, Immunology |
| المصدر: | Neurology, 90, 22, pp. e1997-e2005 Neurology Neurology, 90(22), E1997-E2005. Lippincott Williams & Wilkins Neurology, 90, e1997-e2005 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 050103 clinical psychology, Pediatrics, medicine.medical_specialty, Adolescent, Cross-sectional study, Neuropsychological Tests, Article, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Interquartile range, medicine, Humans, Cognitive Dysfunction, 0501 psychology and cognitive sciences, Neuropsychological assessment, Child, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, medicine.diagnostic_test, business.industry, 05 social sciences, Neuropsychology, Cognition, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Confidence interval, Cross-Sectional Studies, Child, Preschool, Quality of Life, Female, Neurology (clinical), Verbal memory, business, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | ObjectiveTo provide detailed long-term outcome data of children and adolescents following pediatric anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, to identify neuropsychological impairments, and to evaluate the influence of these factors on quality of life (QoL).MethodsAll Dutch children diagnosed with anti-NMDAR encephalitis were identified. Patients currently aged 4 years or older were included in the follow-up study, consisting of a visit to our clinic for a detailed interview and a standardized neuropsychological assessment. The following domains were included: attention, memory, language, executive functioning, QoL, and fatigue. Primary outcome measures were z scores on sustained attention, long-term verbal memory, QoL, fatigue, and working memory.ResultsTwenty-eight patients were included. Median Pediatric Cerebral Performance Category at last visit was 1 (interquartile range 1–2, range 1–4), and 64% (18/28) of patients returned consistently to their previous school level. Twenty-two patients were included in the cross-sectional part of the long-term follow-up study. Median follow-up time was 31 months (interquartile range 15–49, range 5–91). There were problems with sustained attention (z = −2.10, 95% confidence interval = −2.71 to −1.46, p < 0.0001) and fatigue (z = −0.96, 95% confidence interval = −1.64 to −0.28, p = 0.008). Cognitive deficits were not correlated with QoL, while fatigue was strongly correlated with QoL (r = 0.82, p < 0.0001).ConclusionsAlthough follow-up is often reported as “good” following pediatric anti-NMDAR encephalitis, many patients have cognitive problems and fatigue, even up until adolescence, resulting in academic achievement problems and lower QoL. For physicians, it is essential to be aware of these problems, to provide valuable advice to patients and caregivers in the acute and follow-up phase, and to consider early neuropsychological counseling. |
| وصف الملف: | application/pdf |
| تدمد: | 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9389bdd721f94056d60ac6dac7687432Test https://hdl.handle.net/2066/200657Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9389bdd721f94056d60ac6dac7687432 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00283878 |
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