التفاصيل البيبلوغرافية
| العنوان: |
Obesity and HIV: a compounding problem. |
| المؤلفون: |
Biggs, Chara1 biggsc@ukzn.ac.za, Spooner, Elizabeth2 |
| المصدر: |
South African Journal of Clinical Nutrition. Nov2018, Vol. 31 Issue 4, p78-83. 6p. |
| مصطلحات موضوعية: |
*OBESITY risk factors, *ANTIRETROVIRAL agents, *BLOOD protein disorders, *ADIPOSE tissues, *ANEMIA, *BODY composition, *HUMAN body composition, *C-reactive protein, *CHI-squared test, *DISEASES, *FISHER exact test, *HEALTH facilities, *HEMOGLOBINS, *ISOTOPES, *LONGITUDINAL method, *SERUM albumin, *STATISTICS, *DATA analysis, *ALBUMINS, *BODY mass index, *DISEASE prevalence, *CROSS-sectional method, *SEVERITY of illness index, *HIV seroconversion, *DISEASE progression, *DESCRIPTIVE statistics, *CD4 lymphocyte count, *MANN Whitney U Test, *DISEASE risk factors |
| مصطلحات جغرافية: |
SOUTH Africa |
| مستخلص: |
Objectives: A cross-sectional study was undertaken at Lancers Road Clinic, Durban, South Africa to determine body composition, haemoglobin, serum albumin and serum high sensitivity C-reactive protein (hs-CRP) levels in asymptomatic ART-naive HIV positive adults. Methods: All eligible adults attending the clinic were sampled. Body composition was assessed using deuterium dilution. Descriptive statistics, Wilcoxon rank-sum test, chi-square test, Fisher’s exact test and Spearman’s rank correlation coefficient were used for data analysis. Results: A total of 84 participants (CD4 count: 542.5 ± 145 cell/mm3) enrolled. The mean body mass index (BMI) was 29.5 (± 6.4) kg/m2 and the mean fat mass percentage was 44.9 (± 18.7). The prevalence of overweight (26.2%, 22/84) and obesity (46.4%, 39/84) was high. Mean haemoglobin (Hb) levels were 12.0 ± 1.6 g/dl. Mild, moderate and severe anaemia was present in 21.4% (18/84), 20.2% (17/84) and 1.2% (1/84) of patients, respectively. Mean albumin levels (36.2 ± 3.8 g/l) were on the borderline low range of normal with mildly depleted albumin levels being present in a third (32.1%, 27/84) of patients. The mean hs-CRP levels (5.5 ± 7.2 mg/l) were high. Conclusion: In this cohort of patients, wasting was not associated with HIV as the prevalence of overweight/obesity was high and followed the population trend in SA. This seemingly well, asymptomatic population of people living with HIV was at an increased risk of morbidity, progression and death due to the compounding factors of overweight/obesity, hypoalbuminemia, raised hs-CRP levels and anaemia. [ABSTRACT FROM AUTHOR] |
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