Adverse events and patients' perceived health-related quality of life at the end of multidrug-resistant tuberculosis treatment in Namibia
| العنوان: | Adverse events and patients' perceived health-related quality of life at the end of multidrug-resistant tuberculosis treatment in Namibia |
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| المؤلفون: | Sagwa, E., Ruswa, Nunurai C, Mavhunga, Farai, Rennie, Timothy, Leufkens, H.G.M., Teeuwisse, A.K., Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology |
| المساهمون: | Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology |
| المصدر: | Patient Preference and Adherence, 2016(10), 2369. Dove Medical Press Ltd. Patient preference and adherence |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Tuberculosis, drug safety, SF-8™ questionnaire, Medicine (miscellaneous), Perceived health, 03 medical and health sciences, 0302 clinical medicine, Cronbach's alpha, Internal consistency, Medicine, 030212 general & internal medicine, Adverse effect, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Original Research, Median score, patient-reported health outcomes, Alpha Value, business.industry, Health Policy, medicine.disease, SF-8TM questionnaire, Namibia, humanities, 030228 respiratory system, Patient Preference and Adherence, Adverse drug event, Physical therapy, second-line tuberculosis drugs, business, Social Sciences (miscellaneous) |
| الوصف: | Purpose The health-related quality of life (HRQoL) of patients completing multidrug-resistant tuberculosis (MDR-TB) treatment in Namibia and whether the occurrence of adverse events influenced patients’ rating of their HRQoL was evaluated. Patients and methods A cross-sectional analytic survey of patients completing or who recently completed MDR-TB treatment was conducted. The patients rated their HRQoL using the simplified Short Form-™ (SF-8) questionnaire consisting of eight Likert-type questions. Three supplemental questions on the adverse events that the patients may have experienced during their MDR-TB treatment were also included. Scoring of HRQoL ratings was norm-based (mean =50, standard deviation =10) ranging from 20 (worst health) to 80 (best health), rather than the conventional 0–100 scores. We evaluated the internal consistency of the scale items using the Cronbach’s alpha, performed descriptive analyses, and analyzed the association between the patients’ HRQoL scores and adverse events. Results Overall, 36 patients (20 males, 56%) aged 17–54 years (median =40 years) responded to the questionnaire. The median (range) HRQoL score for the physical component summary was 58.6 (35.3–60.5), while the median score for the mental component summary was 59.3 (26.6–61.9), indicating not-so-high self-rating of health. There was good internal consistency of the scale scores, with a Cronbach’s alpha value of >0.80. In all, 32 (89%) of the 36 patients experienced at least one adverse drug event of any severity during their treatment (median events =3, range 1–6), of which none was life-threatening. The occurrence of adverse events was not related to HRQoL scores. For patients reporting zero to two events, the median (range) HRQoL score was 56.8 (44.4–56.8), while for those reporting three or more events, the median score was 55.2 (38.6–56.8); P=0.34 for difference between these scores. Conclusion Patients completing treatment for MDR-TB in Namibia tended to score moderately low on their HRQoL, using the generic SF-8 questionnaire. The occurrence of adverse events did not lead to lower HRQoL scores upon treatment completion. Video abstract |
| وصف الملف: | text/html; image/pdf |
| اللغة: | English |
| تدمد: | 1177-889X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23099dba4113b57c493e8a96a8bccf89Test https://doi.org/10.2147/ppa.s116860Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....23099dba4113b57c493e8a96a8bccf89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1177889X |
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