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Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

التفاصيل البيبلوغرافية
العنوان: Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure
المؤلفون: Dumas, Guillaume, Demoule, Alexandre, Mokart, Djamel, Lemiale, Virginie, Nseir, Saad, Argaud, Laurent, Pène, Frédéric, Kontar, Loay, Bruneel, Fabrice, Klouche, Kada, Barbier, François, Reignier, Jean, Stoclin, Annabelle, Louis, Guillaume, Constantin, Jean-Michel, Wallet, Florent, Kouatchet, Achille, Peigne, Vincent, Perez, Pierre, Girault, Christophe, Jaber, Samir, Cohen, Yves, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lebert, Christine, Lautrette, Alexandre, Bigé, Naïke, Raphalen, Jean-Herlé, Papazian, Laurent, Benoit, Dominique, Darmon, Michael, Chevret, Sylvie, Azoulay, Elie
المساهمون: Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint Louis [APHP], Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Intensive Care Unit, IPC, Urgence respiratoire et réanimation médicale, Hôpital Roger Salengro-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Cochin [AP-HP], CHU Amiens-Picardie, Hôpital Andre Mignot, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), La Source Hospital-CHR, Centre hospitalier universitaire de Nantes (CHU Nantes), Institut Gustave Roussy (IGR), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), CHU Pitié-Salpêtrière [APHP], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Métropole-Savoie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Rouen, Normandie Université (NU), Hôpital d'Avicenne, Centre Hospitalier de Roubaix, CHU Grenoble, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Départemental Les Oudairies, Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184, Rue du Faubourg-Saint-Antoine, 75571 Paris Cedex 12, Paris, France., CHU Necker - Enfants Malades [AP-HP], Hôpital Nord AP‐MM Marseille, France (AP‐MM Marseille), Ghent University Hospital [Ghent, Belgium], Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Cochin [AP-HP], Centre Hospitalier de Versailles André Mignot (CHV), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Avicenne [AP-HP], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], MORNET, Dominique
المصدر: Critical Care
Critical Care, BioMed Central, 2019, 23 (1), pp.306. ⟨10.1186/s13054-019-2590-7⟩
Critical Care, Vol 23, Iss 1, Pp 1-10 (2019)
CRITICAL CARE
Critical Care, 2019, 23 (1), pp.306. ⟨10.1186/s13054-019-2590-7⟩
بيانات النشر: HAL CCSD, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, Neutropenia, Critical Illness, [SDV]Life Sciences [q-bio], Comorbidity, THERAPY, Risk Assessment, OXYGEN, ACUTE LUNG INJURY, NONINVASIVE VENTILATION, Cohort Studies, Hypoxemia, Immunocompromised Host, PERMUTATION TESTS, Medicine and Health Sciences, Humans, VARIANCE-COMPONENTS, MULTILEVEL LOGISTIC-REGRESSION, Aged, OUTCOMES, Leukemia, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Oxygen Inhalation Therapy, lcsh:RC86-88.9, Middle Aged, Center effect, [SDV] Life Sciences [q-bio], Intensive Care Units, Female, Respiratory Insufficiency, Intubation
الوصف: Background Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in randomized controlled trials (RCTs). However, data are lacking on whether intubation is an objective criteria that is used unbiasedly across centers. This study explores how this outcome varies across ICUs. Methods Hierarchical models and permutation procedures for testing multiple random effects were applied on both data from an observational cohort (the TRIAL-OH study: 703 patients, 17 ICUs) and a randomized controlled trial (the HIGH trial: 776 patients, 31 ICUs) to characterize ICU variation in intubation risk across centers. Results The crude intubation rate varied across ICUs from 29 to 80% in the observational cohort and from 0 to 86% in the RCT. This center effect on the mean ICU intubation rate was statistically significant, even after adjustment on individual patient characteristics (observational cohort: p value = 0.013, median OR 1.48 [1.30–1.72]; RCT: p value 0.004, median OR 1.51 [1.36–1.68]). Two ICU-level characteristics were associated with intubation risk (the annual rate of intubation procedure per center and the time from respiratory symptoms to ICU admission) and could partly explain this center effect. In the RCT that controlled for the use of high-flow oxygen therapy, we did not find significant variation in the effect of oxygenation strategy on intubation risk across centers, despite a significant variation in the need for invasive mechanical ventilation. Conclusion Intubation rates varied considerably among ICUs, even after adjustment on individual characteristics. Electronic supplementary material The online version of this article (10.1186/s13054-019-2590-7) contains supplementary material, which is available to authorized users.
وصف الملف: application/pdf
اللغة: English
تدمد: 1364-8535
1466-609X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::34aaed48d7918876e7c126d274d6b14fTest
https://hal.archives-ouvertes.fr/hal-02281121Test
حقوق: OPEN
رقم الانضمام: edsair.pmid.dedup....34aaed48d7918876e7c126d274d6b14f
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13648535
1466609X