Impact of dyslipidemia on estimated glomerular filtration rate in apparently healthy children and adolescents: the CASPIAN-V study
| العنوان: | Impact of dyslipidemia on estimated glomerular filtration rate in apparently healthy children and adolescents: the CASPIAN-V study |
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| المؤلفون: | Mehri Khoshhali, Mohammad Moafi, Mostafa Qorbani, Farahnak Assadi, Majzoubeh Taheri, Roya Kelishadi, Ramin Heshmat, Razieh Dashti, Mohammad Esmaeil Motlagh |
| المصدر: | World Journal of Pediatrics. 15:471-475 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Renal function, Iran, Risk Assessment, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, Sex Factors, 0302 clinical medicine, 030225 pediatrics, Internal medicine, medicine, Humans, 030212 general & internal medicine, Risk factor, Child, Dyslipidemias, Creatinine, medicine.diagnostic_test, business.industry, medicine.disease, Blood pressure, chemistry, Pediatrics, Perinatology and Child Health, Female, Lipid profile, business, Body mass index, Biomarkers, Dyslipidemia, Glomerular Filtration Rate, Kidney disease |
| الوصف: | Chronic kidney disease (CKD) is a leading risk factor for development of cardiovascular disease (CVD). Dyslipidemia is also known as risk factor for CVD development. However, the association of dyslipidemia with glomerular injury among healthy children and adolescents remains controversial. We aimed to investigate the relationship between estimated glomerular filtration rate (eGFR) and lipid profile risk factors among healthy children and adolescents. In this nationwide survey, 3808 participants (1992 males, 1816 females), aged 7–18 years, were selected by cluster random sampling method from 30 provinces in Iran. Body mass index (BMI) and systolic and diastolic blood pressures were measured. Blood samples were obtained for serum creatinine, fasting blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) determinations. GFR was estimated using Schwartz equation. Girls had higher eGFR than boys (P = 0.04). In a multiple regression analysis, eGFR demonstrated a positive correlation with systolic blood pressure, BMI, fasting glucose, TC, HDL-C, and TG. By the analysis of covariance, TC, HDL-C, and TG showed a negative correlation with eGFR after adjustments for BMI, systolic and diastolic blood pressures, and fasting glucose (OR = 0.56, 95% CI = 0.29–0.89). The study showed that dyslipidemia is associated with reduced eGFR among the healthy children and adolescents. |
| تدمد: | 1867-0687 1708-8569 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93717ff23922d40631cfce5375e4c3acTest https://doi.org/10.1007/s12519-019-00270-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....93717ff23922d40631cfce5375e4c3ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18670687 17088569 |
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