Institut Català de la Salut, [Torres A] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Institut d’Investigacions August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. Servei de Pneumologia i Al·lèrgia Respiratòria, Hospital Clínic, 08036 Barcelona, Spain. [Motos A, Fernández-Barat L] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Institut d’Investigacions August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. [Riera J, Ferrer R] Servei de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ceccato A] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Pérez-Arnal R] Barcelona Supercomputing Center (BSC), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació
المصدر:
CRITICAL CARE r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Dipòsit Digital de la UB Universidad de Barcelona Scientia Critical Care r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol Critical care (London, England) r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) Critical Care, Vol 25, Iss 1, Pp 1-13 (2021) Scopus Repositorio Abierto de la UdL Universitad de Lleida UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) RUO. Repositorio Institucional de la Universidad de Oviedo
Following publication of the original article at https://doi.org/10.1186/s13054-021-03727-xTest the authors identified an error in the Funding section that has been corrected (https://doi.org/10.1186/s13054-021-03849-2Test) Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.
