دورية أكاديمية
Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality
| العنوان: | Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality |
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| المؤلفون: | Martinez-Lopez, Joaquin, Mateos, María-Victoria, Encinas, Cristina, Sureda, Anna, Hernández-Rivas, José Ángel, Lopez de la Guía, Ana, Gironella Mesa, Mercedes |
| المساهمون: | Institut Català de la Salut, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Mieloma múltiple, COVID-19 (Malaltia), Mortalitat, DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células plasmáticas::mieloma múltiple, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::mortalidad |
| الوصف: | Malalties infeccioses; Mieloma; Pronòstic ; Enfermedades infecciosas; Mieloma; Pronóstico ; Infectious diseases; Myeloma; Prognosis ; There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate–severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2044-5385 |
| العلاقة: | Blood Cancer Journal;10; https://doi.org/10.1038/s41408-020-00372-5Test; Martínez-López J, Mateos MV, Encinas C, Sureda A, Hernández-Rivas JÁ, Lopez de la Guía A, et al. Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality. Blood Cancer J. 2020 Oct 19;10:103.; https://hdl.handle.net/11351/6282Test; 000586453500001 |
| DOI: | 10.1038/s41408-020-00372-5 |
| الإتاحة: | https://doi.org/10.1038/s41408-020-00372-5Test https://hdl.handle.net/11351/6282Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6F34DBFA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20445385 |
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| DOI: | 10.1038/s41408-020-00372-5 |