المؤلفون: Teresa Kösel, Zoë H. Jukes, Tsz Lam M. Wong, Dominic P. Affron, Chun‐Ting Liu, Alan Armstrong, Gregory B. Craven, Rhodri M. L. Morgan, David J. Mann

المساهمون: Cancer and Polio Research Fund Ltd, Engineering & Physical Science Research Council (E

المصدر: Chembiochem

مصطلحات موضوعية: Models, Molecular, Cdk2, Biochemistry & Molecular Biology, Fragment-based drug discovery, Irreversible inhibition kinetics, electrophile-sensitive inhibition, CHEMICAL-GENETIC APPROACH, Fragment-based lead discovery, Kinetic analysis, Chemistry, Medicinal, Crystallography, X-Ray, 0601 Biochemistry and Cell Biology, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, DESIGN, Fragment (logic), Humans, Cysteine, Pharmacology & Pharmacy, Molecular Biology, Fluorescent Dyes, Acrylamide, Science & Technology, Molecular Structure, Full Paper, 0304 Medicinal and Biomolecular Chemistry, 010405 organic chemistry, Chemistry, Tethering, Phosphotransferases, Organic Chemistry, Full Papers, Combinatorial chemistry, covalent fragments, Receptor–ligand kinetics, 0104 chemical sciences, Kinetics, Covalent bond, Thermodynamics, Molecular Medicine, covalent inhibition kinetics, INHIBITORS, Life Sciences & Biomedicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc64dad8bd162bde83f607eccec6cbeTest
https://doi.org/10.1002/cbic.202000457Test

المؤلفون: Rona R. Ramsay, Matteo Pappalardo, Livia Basile, Maria Chiara Saija, Stefanie Hagenow, Sharon D. Bryant, Antonin Maniquet, Alen Albreht, Salvatore Guccione

المساهمون: University of St Andrews. School of Biology

المصدر: Molecules, Vol 25, Iss 5908, p 5908 (2020)
Molecules
Volume 25
Issue 24

مصطلحات موضوعية: computational modeling, Time Factors, QH301 Biology, Molecular Conformation, Pharmaceutical Science, Analytical Chemistry, Substrate Specificity, spectrum, chemistry.chemical_compound, 0302 clinical medicine, enzyme kinetics, Drug Discovery, Neurotransmitter metabolism, QD, 0303 health sciences, biology, adduct, Molecular Structure, Irreversible inhibition, Computational modeling, Molecular Docking Simulation, Chemistry (miscellaneous), Covalent bond, Molecular Medicine, Adduct, Oxidation-Reduction, Protein Binding, RM, Monoamine Oxidase Inhibitors, Monoamine oxidase, Stereochemistry, Imine, Flavin group, Molecular Dynamics Simulation, Cofactor, Article, lcsh:QD241-441, 03 medical and health sciences, QH301, Inhibitory Concentration 50, Structure-Activity Relationship, SDG 3 - Good Health and Well-being, lcsh:Organic chemistry, Spectrum, Humans, FAD, irreversible inhibition, enzyme kinetics, computational modeling, pharmacophore, spectrum, adduct, Physical and Theoretical Chemistry, Binding site, Monoamine Oxidase, 030304 developmental biology, irreversible inhibition, Binding Sites, Pharmacophore, Dose-Response Relationship, Drug, pharmacophore, FAD, Organic Chemistry, Enzyme kinetics, DAS, QD Chemistry, RM Therapeutics. Pharmacology, Enzyme Activation, Kinetics, chemistry, biology.protein, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcd8edd8493c4c963ee67729f94cea6Test
https://www.mdpi.com/1420-3049/25/24/5908Test

المؤلفون: Theodoros Goulas, Aniebrys Marrero, Irene Garcia-Ferrer, Laura Marino-Puertas, Stéphane Duquerroy, F. Xavier Gomis-Rüth

المساهمون: European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Educación y Cultura (España)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, Steric effects, Clinical Biochemistry, Cleavage (embryo), medicine.disease_cause, Biochemistry, 03 medical and health sciences, Broad spectrum, Endopeptidases, medicine, Animals, Humans, Protease Inhibitors, alpha-Macroglobulins, Protein Structure, Quaternary, Molecular Biology, Escherichia coli, Protein inhibitor, chemistry.chemical_classification, Regulation of proteolytic activity, 030102 biochemistry & molecular biology, Irreversible inhibition, Endopeptidase, 3. Good health, 030104 developmental biology, Enzyme, chemistry, Macroglobulins, Covalent bond, Multi-domain protein, Bait region cleavage, Biophysics, Protein Multimerization, Conformational rearrangement

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0572e72d14e12ca1fd312bec84f64f6cTest
https://doi.org/10.1515/hsz-2016-0329Test

المؤلفون: Marco Mor, Silvia Rivara, Caterina Carmi, Andrea Ardizzoni, Alessio Lodola, Andrea Cavazzoni, Pier Giorgio Petronini, Federica Vacondio, Roberta Alfieri

المساهمون: C. Carmi, A. Lodola, S. Rivara, F. Vacondio, A. Cavazzoni, R.R. Alfieri, A. Ardizzoni, P.G. Petronini, M. Mor

المصدر: ResearcherID

مصطلحات موضوعية: Pharmacology, biology, Kinase, Receptor Protein-Tyrosine Kinases, General Medicine, antitumor, covalent inhibition, cysteine-trap, EGFR, erbB receptor, irreversible inhibition, NSCLC, ErbB Receptors, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Biochemistry, Covalent bond, Acrylamide, Drug Discovery, biology.protein, Humans, Structure–activity relationship, Cysteine, Epidermal growth factor receptor, Protein Kinase Inhibitors

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7984ba1809e3f0bc1f25ebc8686bf0daTest
https://doi.org/10.2174/138955711797247725Test

المؤلفون: Denise M. G. Freire, Evelin A. Manoel, José C. S. dos Santos, Roberto Fernandez-Lafuente, Nazzoly Rueda

المساهمون: Ministerio de Economía y Competitividad (España), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Colciencias (Colombia), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Protein Conformation, Detergents, Bioengineering, Burkholderia cepacia, Applied Microbiology and Biotechnology, Biochemistry, Fungal Proteins, Octyl-agarose, chemistry.chemical_compound, Ascomycota, Bacterial Proteins, Ionic strength, Open form, Cyanogen Bromide, chemistry.chemical_classification, Chromatography, biology, Chemistry, Interfacial activation, Sepharose, Pseudomonas, Osmolar Concentration, technology, industry, and agriculture, Substrate (chemistry), Irreversible inhibition, Lipase, biology.organism_classification, Enzymes, Immobilized, Lipase immobilization, Kinetics, Enzyme, Covalent bond, Agarose, Cyanogen bromide, lipids (amino acids, peptides, and proteins), Hydrophobic and Hydrophilic Interactions, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449787c518fee18ce653e6397031aa30Test
http://hdl.handle.net/10261/190628Test

المؤلفون: Soumendranath Bhakat, Hezekiel Kumalo, Mahmoud Soliman

المصدر: Molecules
Molecules, Vol 20, Iss 2, Pp 1984-2000 (2015)

مصطلحات موضوعية: Pharmaceutical Science, Review, Molecular Docking Simulation, Analytical Chemistry, lcsh:QD241-441, covalent inhibition, lcsh:Organic chemistry, Drug Discovery, covalent interactions, Humans, Physical and Theoretical Chemistry, irreversible inhibition, Chemistry, Drug discovery, Organic Chemistry, Highly selective, Combinatorial chemistry, covalent docking, Chemistry (miscellaneous), Docking (molecular), Covalent bond, Molecular Medicine, Thermodynamics, Target protein, Software, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb83d838ad63cf963ecdc4d880daeb9Test
https://pubmed.ncbi.nlm.nih.gov/25633330Test

المؤلفون: Arwin J. Brouwer, Helmus van de Langemheen, Rob M. J. Liskamp, Adriano Ciaffoni, Natalia Herrero Alvarez

المصدر: Bioorganic and Medicinal Chemistry, 24(16), 3429. Elsevier

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Spectrometry, Mass, Electrospray Ionization, Double bond, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Pharmaceutical Science, Context (language use), 010402 general chemistry, 01 natural sciences, Biochemistry, Fluorides, Drug Discovery, Moiety, Sulfones, Carbon-13 Magnetic Resonance Spectroscopy, Molecular Biology, Chromatography, High Pressure Liquid, irreversible inhibition, Sulfonyl, chemistry.chemical_classification, biology, 010405 organic chemistry, Organic Chemistry, Active site, peptido vinyl sulfonyl fluoride, 0104 chemical sciences, proteasome, chemistry, Proteasome, Covalent bond, Drug Design, dual warhead, Electrophile, biology.protein, Molecular Medicine, Peptides, Proteasome Inhibitors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c192c1da5b3ced55260e44ac74ecaTest
https://doi.org/10.1016/j.bmc.2016.05.042Test