Genomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020
| العنوان: | Genomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020 |
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| المؤلفون: | Chul-Un Chung, Hee-Chun Chung, Cheong-Ung Kim, Kuem-Chan Jang, Sook Shin, Yong-Shin Jeon, Bong-Kyun Park, Aeri Kong, Le Bich Hang Pham, Hai-Quynh Do, Yong Ho Park, Van Giap Nguyen |
| المصدر: | Viruses Volume 13 Issue 10 Viruses, Vol 13, Iss 2041, p 2041 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | bat, Genome, Viral, Biology, medicine.disease_cause, Microbiology, Genetic analysis, Genome, Alphacoronavirus, Article, Phylogenetics, Chiroptera, Virology, Republic of Korea, medicine, Animals, Amino Acid Sequence, Phylogeny, Artiodactyla, Coronavirus, Whole genome sequencing, Genetics, Korea, Whole Genome Sequencing, Phylogenetic tree, Strain (biology), novel species, biology.organism_classification, QR1-502, Infectious Diseases, Coronavirus Infections, Sequence Alignment |
| الوصف: | Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (Eptesicus serotinus), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the Alphacoronavirus genus. Phylogenetic construction indicated that this strain formed a separated branch with other species, suggesting a new species of Alphacoronavirus. Additionally, in silico prediction also revealed the risk of cross-species infection of this strain, especially in the order Artiodactyla. In summary, this study provided the genetic characteristics of a possible new species belonging to Alphacoronavirus. |
| وصف الملف: | application/pdf |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641b6e3e78adff91f5c6a3ada2923664Test https://doi.org/10.3390/v13102041Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....641b6e3e78adff91f5c6a3ada2923664 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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