دورية أكاديمية
Prevalence and predictors of abnormal cardiovascular responses to exercise testing among individuals with type 2 diabetes the look AHEAD (Action for Health in Diabetes) study
| العنوان: | Prevalence and predictors of abnormal cardiovascular responses to exercise testing among individuals with type 2 diabetes the look AHEAD (Action for Health in Diabetes) study |
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| المؤلفون: | Curtis, JM, Horton, ES, Bahnson, J, Gregg, EW, Jakicic, JM, Regensteiner, JG, Ribisl, PM, Soberman, JE, Stewart, KJ, Espeland, MA |
| المصدر: | 907 ; 901 |
| بيانات النشر: | American Diabetes Association |
| سنة النشر: | 2010 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, CORONARY-HEART-DISEASE, BLOOD-PRESSURE, PULSE PRESSURE, RISK-FACTORS, TREADMILL EXERCISE, CLINICAL-TRIAL, MEN, MORTALITY, CAPACITY, PERFORMANCE, Aged, Cardiovascular Diseases, Cardiovascular System, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Exercise Test, Female, Humans, Male, Middle Aged, Look AHEAD Research Group, 11 Medical and Health Sciences |
| الوصف: | OBJECTIVE We examined maximal graded exercise test (GXT) results in 5,783 overweight/obese men and women, aged 45–76 years, with type 2 diabetes, who were entering the Look AHEAD (Action for Health in Diabetes) study, to determine the prevalence and correlates of exercise-induced cardiac abnormalities. RESEARCH DESIGN AND METHODS Participants underwent symptom-limited maximal GXTs. Questionnaires and physical examinations were used to determine demographic, anthropometric, metabolic, and health status predictors of abnormal GXT results, which were defined as an ST segment depression ≥1.0 mm, ventricular arrhythmia, angina pectoris, poor postexercise heart rate recovery (<22 bpm reduction 2 min after exercise), or maximal exercise capacity less than 5.0 METs. Systolic blood pressure response to exercise was examined as a continuous variable, without a threshold to define abnormality. RESULTS Exercise-induced abnormalities were present in 1,303 (22.5%) participants, of which 693 (12.0%) consisted of impaired exercise capacity. ST segment depression occurred in 440 (7.6%), abnormal heart rate recovery in 206 (5.0%), angina in 63 (1.1%), and arrhythmia in 41 (0.7%). Of potential predictors, only greater age was associated with increased prevalence of all abnormalities. Other predictors were associated with some, but not all, abnormalities. Systolic blood pressure response decreased with greater age, duration of diabetes, and history of cardiovascular disease. CONCLUSIONS We found a high rate of abnormal GXT results despite careful screening for cardiovascular disease symptoms. In this cohort of overweight and obese individuals with type 2 diabetes, greater age most consistently predicted abnormal GXT. Long-term follow-up of these participants will show whether these abnormalities are clinically significant. Cardiovascular disease (CVD) risk factors improve with exercise in individuals with diabetes (1). Similarly, individuals with diabetes who are physically active or have higher fitness levels have reduced CVD ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0149-5992 |
| العلاقة: | Diabetes Care; http://hdl.handle.net/10044/1/71799Test; https://doi.org/10.2337/dc09-1787Test |
| DOI: | 10.2337/dc09-1787 |
| الإتاحة: | https://doi.org/10.2337/dc09-1787Test http://hdl.handle.net/10044/1/71799Test |
| حقوق: | © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommonsTest. org/licenses/by-nc-nd/3.0/ for details. |
| رقم الانضمام: | edsbas.BE5DE86B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01495992 |
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| DOI: | 10.2337/dc09-1787 |