التفاصيل البيبلوغرافية
| العنوان: |
Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats |
| المؤلفون: |
Kenichi Mishima, Takashi Egawa, Katsunori Iwasaki, Eunhee Chung, Michihiro Fujiwara, Keiichi Irie, Nobuaki Egashira, Izzettin Hatip-Al-Khatib |
| بيانات النشر: |
Elsevier, 2004. |
| سنة النشر: |
2004 |
| مصطلحات موضوعية: |
hippocampus, nerve degeneration, Apoptosis, Hippocampal formation, Repeated ischemia, dizocilpine, animal, rat, AMPA receptor, rat strain, cell count, comparative study, pathophysiology, Neurons, MK-801, quantitative analysis, brain perfusion, General Neuroscience, drug effect, Glutamate receptor, neuroprotective agent, article, memory disorder, spatial memory, Receptor antagonist, YM-90K, reperfusion injury, n methyl dextro aspartic acid receptor, dizocilpine maleate, unclassified drug, reperfusion, Neuroprotective Agents, n methyl dextro aspartic acid receptor blocking agent, priority journal, 6 (1 imidazolyl) 7 nitro 2,3 quinoxalinedione, NMDA receptor, neuroprotection, nerve cell, medicine.medical_specialty, medicine.drug_class, regulatory mechanism, animal experiment, Ischemia, 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione, Biology, Receptors, N-Methyl-D-Aspartate, Neuroprotection, animal tissue, male, Quinoxalines, Internal medicine, medicine, Animals, controlled study, maze test, Receptors, AMPA, Rats, Wistar, Maze Learning, Molecular Biology, amino acid receptor blocking agent, Memory Disorders, nonhuman, nerve cell necrosis, animal model, disease model, AMPA receptor antagonist, Antagonist, Recovery of Function, convalescence, medicine.disease, brain cell, brain ischemia, Rats, Disease Models, Animal, Endocrinology, physiology, Neurology (clinical), quinoxaline derivative, Excitatory Amino Acid Antagonists, metabolism, Developmental Biology |
| الوصف: |
The spatial memory impairment and expression of apoptotic cells in hippocampal CA1 cells were investigated in rats using single and repeated ischemia models. The neuroprotective and memory-improving effect of YM-90K, an ?-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonist, was compared to MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. Twice-repeated ischemia, but not single ischemia, impaired the spatial memory and increased expression of apoptotic cells. YM-90K, given before and 6 h after the second reperfusion, significantly improved the memory and reduced the apoptotic cells 7 days after the second reperfusion in repeated ischemia. MK-801 neither improved the spatial memory nor reduced apoptotic cells. The present study showed that delayed expression of apoptotic cells is mediated by mechanisms involving AMPA receptors, but not by NMDA receptor, during the late phase after reperfusion. YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia. © 2003 Elsevier B.V. All rights reserved. |
| اللغة: |
English |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c073169306a20a709782afe98859d191Test
https://doi.org/10.1016/j.brainres.2003.09.064Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....c073169306a20a709782afe98859d191 |
| قاعدة البيانات: |
OpenAIRE |
