دورية أكاديمية
High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)
| العنوان: | High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study) |
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| المؤلفون: | Milési, Christophe, Essouri, Sandrine, Pouyau, Robin, Liet, Jean-Michel, Afanetti, Mickael, Portefaix, Aurélie, Baleine, Julien, Durand, Sabine, Combes, Clémentine, Douillard, Aymeric, Cambonie, Gilles, (gfrup), Groupe Francophone de Réanimation Et D’urgences Pédiatriques |
| المساهمون: | Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Femme Mère Enfant CHU - HCL (HFME), Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre Hospitalier Universitaire de Nice (CHU Nice), CIC 1407 |
| المصدر: | ISSN: 0342-4642. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Bronchiolitis, Continuous positive airway pressure, High flow nasal cannula, Infant, Noninvasive ventilation, Oxygen inhalation therapy, Randomized controlled trial, Respiratory syncytial virus infections, Respiratory therapy, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; PURPOSE:Nasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants.METHODS:A randomized controlled trial was performed in five pediatric intensive care units (PICUs) to compare 7 cmH2O nCPAP with 2 L/kg/min oxygen therapy administered with HFNC in infants up to 6 months old with moderate to severe AVB. The primary endpoint was the percentage of failure within 24 h of randomization using prespecified criteria. To satisfy noninferiority, the failure rate of HFNC had to lie within 15% of the failure rate of nCPAP. Secondary outcomes included success rate after crossover, intubation rate, length of stay, and serious adverse events.RESULTS:From November 2014 to March 2015, 142 infants were included and equally distributed into groups. The risk difference of -19% (95% CI -35 to -3%) did not allow the conclusion of HFNC noninferiority (p = 0.707). Superiority analysis suggested a relative risk of success 1.63 (95% CI 1.02-2.63) higher with nCPAP. The success rate with the alternative respiratory support, intubation rate, durations of noninvasive and invasive ventilation, skin lesions, and length of PICU stay were comparable between groups. No patient had air leak syndrome or died.CONCLUSION:In young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP. This clinical trial was recorded in the National Library of Medicine registry (NCT 02457013). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28124736; hal-01791042; https://hal.science/hal-01791042Test; PUBMED: 28124736 |
| DOI: | 10.1007/s00134-016-4617-8 |
| الإتاحة: | https://doi.org/10.1007/s00134-016-4617-8Test https://hal.science/hal-01791042Test |
| رقم الانضمام: | edsbas.4A69D25A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00134-016-4617-8 |
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