Behavioral and brain signatures of substance use vulnerability in childhood
| العنوان: | Behavioral and brain signatures of substance use vulnerability in childhood |
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| المؤلفون: | Kristina M. Rapuano, B. J. Casey, R. Todd Constable, Nicholas J. Dennis, Maria T. Maza, Dustin Scheinost, Monica D. Rosenberg, Corey Horien, Abigail S. Greene, Mila Dorji |
| المصدر: | Developmental Cognitive Neuroscience Developmental Cognitive Neuroscience, Vol 46, Iss, Pp 100878-(2020) |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cognitive Neuroscience, media_common.quotation_subject, Vulnerability, Poison control, Stop signal, Substance use, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Cognitive development, medicine, 0501 psychology and cognitive sciences, Original Research, media_common, Addiction, lcsh:QP351-495, 05 social sciences, Human factors and ergonomics, medicine.disease, Regression, Substance abuse, Functional imaging, lcsh:Neurophysiology and neuropsychology, Connectome-based predictive modeling, Connectome, ABCD, Psychology, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | The prevalence of risky behavior such as substance use increases during adolescence; however, the neurobiological precursors to adolescent substance use remain unclear. Predictive modeling may complement previous work observing associations with known risk factors or substance use outcomes by developing generalizable models that predict early susceptibility. The aims of the current study were to identify and characterize behavioral and brain models of vulnerability to future substance use. Principal components analysis (PCA) of behavioral risk factors were used together with connectome-based predictive modeling (CPM) during rest and task-based functional imaging to generate predictive models in a large cohort of nine- and ten-year-olds enrolled in the Adolescent Brain & Cognitive Development (ABCD) study (NDA release 2.0.1). Dimensionality reduction (n=9,437) of behavioral measures associated with substance use identified two latent dimensions that explained the largest amount of variance: risk-seeking (PC1; e.g., curiosity to try substances) and familial factors (PC2; e.g., family history of substance use disorder). Using cross-validated regularized regression in a subset of data (Year 1 Fast Track data; n>1,500), functional connectivity during rest and task conditions (resting-state; monetary incentive delay task; stop signal task; emotional n-back task) significantly predicted individual differences in risk-seeking (PC1) in held-out participants (partial correlations between predicted and observed scores controlling for motion and number of frames [rp]: 0.07-0.21). By contrast, functional connectivity was a weak predictor of familial risk factors associated with substance use (PC2) (rp: 0.03-0.06). These results demonstrate a novel approach to understanding substance use vulnerability, which—together with mechanistic perspectives—may inform strategies aimed at early identification of risk for addiction. |
| تدمد: | 1878-9293 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357d42a8ce2afdaf1316ee195169e01cTest https://doi.org/10.1016/j.dcn.2020.100878Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....357d42a8ce2afdaf1316ee195169e01c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18789293 |
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