المؤلفون: Berenji, Kambeez¹, Drazner, Mark H.^1,2 mark.drazner@utsouthwestern.edu, Rothermel, Beverly A.¹, Hill, Joseph A.^1,2,3

المصدر: American Journal of Physiology: Heart & Circulatory Physiology. Jul2005, Vol. 289 Issue 1, pH8-H16. 9p.

مصطلحات موضوعية: *HYPERTROPHY, *HEART failure risk factors, *CORONARY disease, *CONGESTIVE heart failure, *HEART diseases, *CARDIOLOGY

مستخلص: Ventricular hypertrophy develops in response to numerous forms of cardiac stress, including pressure or volume overload, loss of contractile mass from prior infarction, neuroendocrine activation, and mutations in genes encoding sarcomeric proteins. Hypertrophic growth is believed to have a compensatory role that diminishes wall stress and oxygen consumption, but Framingham and other studies established ventricular hypertrophy as a marker for increased risk of developing chronic heart failure, suggesting that hypertrophy may have maladaptive features. However, the relative contribution of comorbid disease to hypertrophy-associated systolic failure is unknown. For instance, coronary artery disease is induced by many of the same risk factors that cause hypertrophy and can itself lead to systolic dysfunction. It is uncertain, therefore, whether ventricular hypertrophy commonly progresses to systolic dysfunction without the contribution of intervening ischemia or infarction. In this review, we summarize findings from epidemiologic studies, preclinical experiments in animals, and clinical trials to lay out what is known—and not known—about this important question. [ABSTRACT FROM AUTHOR]

المؤلفون: Yancy, Clyde W., Jessup, Mariell, Bozkurt, Biykem, Butler, Javed, Casey, Donald E., Drazner, Mark H., Fonarow, Gregg C., Geraci, Stephen A., Horwich, Tamara, Januzzi, James L., Johnson, Maryl R., Kasper, Edward K., Levy, Wayne C., Masoudi, Frederick A., McBride, Patrick E., McMurray, John J.V., Mitchell, Judith E., Peterson, Pamela N., Riegel, Barbara, Sam, Flora, Stevenson, Lynne W., Tang, W. H. Wilson, Tsai, Emily J., Wilkoff, Bruce L.

المصدر: Journal of the American College of Cardiology. (16):1495-1539

مصطلحات موضوعية: ACCF/AHA Practice Guidelines, congestive heart failure, CV surgery: transplantation, ventricular assistance, cardiomyopathy, heart failure, epidemiology, health policy and outcome research, cardio-renal physiology/pathophysiology, other heart failure

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0bd861ca5bd14c9a81a9c8a3eac53383Test

المؤلفون: Heidenreich, Paul A.¹ (AUTHOR), Bozkurt, Biykem¹ (AUTHOR), Aguilar, David¹ (AUTHOR), Allen, Larry A.¹ (AUTHOR), Byun, Joni J.¹ (AUTHOR), Colvin, Monica M.¹ (AUTHOR), Deswal, Anita² (AUTHOR), Drazner, Mark H.¹ (AUTHOR), Dunlay, Shannon M.¹ (AUTHOR), Evers, Linda R.¹ (AUTHOR), Fang, James C.¹ (AUTHOR), Fedson, Savitri E.¹ (AUTHOR), Fonarow, Gregg C.³ (AUTHOR), Hayek, Salim S.¹ (AUTHOR), Hernandez, Adrian F.² (AUTHOR), Khazanie, Prateeti¹ (AUTHOR), Kittleson, Michelle M.¹ (AUTHOR), Lee, Christopher S.¹ (NURSE), Link, Mark S.¹ (AUTHOR), Milano, Carmelo A.¹ (AUTHOR)

المصدر: Circulation. 5/3/2022, Vol. 145 Issue 18, pe895-e1032. 138p.

مصطلحات موضوعية: *HEART failure treatment, *CARDIOLOGY, *REPORT writing, *CARDIOVASCULAR system, *HEART failure

مصطلحات جغرافية: UNITED States

الشركة/الكيان: AMERICAN Heart Association

مستخلص: Aim: The "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure" replaces the "2013 ACCF/AHA Guideline for the Management of Heart Failure" and the "2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure." The 2022 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.Methods: A comprehensive literature search was conducted from May 2020 to December 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (PubMed), EMBASE, the Cochrane Collaboration, the Agency for Healthcare Research and Quality, and other relevant databases. Additional relevant clinical trials and research studies, published through September 2021, were also considered. This guideline was harmonized with other American Heart Association/American College of Cardiology guidelines published through December 2021. Structure: Heart failure remains a leading cause of morbidity and mortality globally. The 2022 heart failure guideline provides recommendations based on contemporary evidence for the treatment of these patients. The recommendations present an evidence-based approach to managing patients with heart failure, with the intent to improve quality of care and align with patients' interests. Many recommendations from the earlier heart failure guidelines have been updated with new evidence, and new recommendations have been created when supported by published data. Value statements are provided for certain treatments with high-quality published economic analyses. [ABSTRACT FROM AUTHOR]

المؤلفون: Heidenreich, Paul A.¹ (AUTHOR), Bozkurt, Biykem¹ (AUTHOR), Aguilar, David¹ (AUTHOR), Allen, Larry A.¹ (AUTHOR), Byun, Joni J.¹ (AUTHOR), Colvin, Monica M.¹ (AUTHOR), Deswal, Anita² (AUTHOR), Drazner, Mark H.¹ (AUTHOR), Dunlay, Shannon M.¹ (AUTHOR), Evers, Linda R.¹ (AUTHOR), Fang, James C.¹ (AUTHOR), Fedson, Savitri E.¹ (AUTHOR), Fonarow, Gregg C.³ (AUTHOR), Hayek, Salim S.¹ (AUTHOR), Hernandez, Adrian F.² (AUTHOR), Khazanie, Prateeti¹ (AUTHOR), Kittleson, Michelle M.¹ (AUTHOR), Lee, Christopher S.¹ (NURSE), Link, Mark S.¹ (AUTHOR), Milano, Carmelo A.¹ (AUTHOR)

المصدر: Circulation. 5/3/2022, Vol. 145 Issue 18, pe876-e894. 19p.

مصطلحات موضوعية: *HEART failure treatment, *CARDIOLOGY, *REPORT writing, *CARDIOVASCULAR system, *HEART failure

مصطلحات جغرافية: UNITED States

الشركة/الكيان: AMERICAN Heart Association

مستخلص: Aim: The "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure" replaces the "2013 ACCF/AHA Guideline for the Management of Heart Failure" and the "2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure." The 2022 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.Methods: A comprehensive literature search was conducted from May 2020 to December 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (PubMed), EMBASE, the Cochrane Collaboration, the Agency for Healthcare Research and Quality, and other relevant databases. Additional relevant clinical trials and research studies, published through September 2021, were also considered. This guideline was harmonized with other American Heart Association/American College of Cardiology guidelines published through December 2021. Structure: Heart failure remains a leading cause of morbidity and mortality globally. The 2022 heart failure guideline provides recommendations based on contemporary evidence for the treatment of these patients. The recommendations present an evidence-based approach to managing patients with heart failure, with the intent to improve quality of care and align with patients' interests. Many recommendations from the earlier heart failure guidelines have been updated with new evidence, and new recommendations have been created when supported by published data. Value statements are provided for certain treatments with high-quality published economic analyses. [ABSTRACT FROM AUTHOR]

المؤلفون: Omar, Wally¹ (AUTHOR), Pham, David¹ (AUTHOR), Drazner, Mark H¹ (AUTHOR), Stevenson, Lynne W² (AUTHOR), Thibodeau, Jennifer T¹ (AUTHOR), Tang, W.H.³ (AUTHOR), Lala, Anu⁴ (AUTHOR), Grodin, Justin L¹ (AUTHOR)

المصدر: Circulation. 2018 Supplement, Vol. 138, pA14820-A14820. 1p.

مصطلحات موضوعية: *HEART failure, *EDEMA, *CONGESTIVE heart failure, *HEMODYNAMICS, *ARTERIAL catheterization, *PULMONARY artery

مستخلص: Introduction: The orthodema score (ODS) is a simple score rating the degree of congestion in acute decompensated heart failure (ADHF) that is associated with clinical outcomes. We sought, to determine the association of ODS scores with invasively measured hemodynamics. Hypothesis: We propose that the ODS will be directly correlated with cardiac filling pressures. Methods: We analyzed the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial database. The ODS was based on symptoms of orthopnea (≥2 pillows=2 points, <2 pillows=0 points) and peripheral edema (0/1+=0 points, 2+=1 point, 3+/4+=2 points). ODS scores were classified according to the point total as absent (0 points), low-grade (1-2 points), or high-grade (3-4 points). We tested the association of ODS with baseline right atrial pressure (RAP), mean pulmonary capillary wedge pressure (PCWP), and cardiac index (CI). Results: In our study cohort (N=433, age 56±14 [y], 74% male, 49% ischemic etiology, and ejection fraction 19±7 [%]) the baseline ODS were absent in 10%, low-grade in 58%, and high-grade in 32%. Higher baseline ODS was associated with higher RAP (Figure A. P-trend<0.001), PCWP (Figure B. P-trend=0.03), but not lower CI (Figure C. P-trend=0.07) at baseline. There were 281 (66%) with improvement in their ODS upon discharge. Higher baseline ODS had a trend towards fewer days well and not hospitalized (transplant/LVAD count as dead) by 180 days (high-grade vs. absent ODS HR 1.38, 95% CI [0.98-1.96], P=0.07) while higher discharge ODS was associated with fewer days well and not hospitalized (transplant/LVAD count as dead) by 180days (high-grade vs. absent ODS HR 1.59, 95% CI [1.04-2.45], P=0.03). Conclusion: The ODS is associated with cardiac filling pressures, but not cardiac index. Discharge ODS is more closely related to prognosis than admission ODS. [ABSTRACT FROM AUTHOR]

المؤلفون: Yancy, Clyde W., Jessup, Mariell, Bozkurt, Biykem, Butler, Javed, Casey, Donald E., Drazner, Mark H., Fonarow, Gregg C., Geraci, Stephen A., Horwich, Tamara, Januzzi, James L., Johnson, Maryl R., Kasper, Edward K., Levy, Wayne C., Masoudi, Frederick A., McBride, Patrick E., McMurray, John J.V., Mitchell, Judith E., Peterson, Pamela N., Riegel, Barbara, Sam, Flora

المصدر: Journal of the American College of Cardiology (JACC). Oct2013, Vol. 62 Issue 16, p1495-1539. 45p.

المؤلفون: Yancy, Clyde W., Jessup, Mariell, Bozkurt, Biykem, Butler, Javed, Casey, Donald E., Drazner, Mark H., Fonarow, Gregg C., Geraci, Stephen A., Horwich, Tamara, Januzzi, James L., Johnson, Maryl R., Kasper, Edward K., Levy, Wayne C., Masoudi, Frederick A., McBride, Patrick E., McMurray, John J.V., Mitchell, Judith E., Peterson, Pamela N., Riegel, Barbara, Sam, Flora

المصدر: Journal of the American College of Cardiology (JACC). Oct2013, Vol. 62 Issue 16, pe147-e239. 0p.