التفاصيل البيبلوغرافية
| العنوان: |
BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran. |
| المؤلفون: |
Zafari, Zahra, Ayatollahi, Hossein, Sohrabi, Tayebeh, Jafari, Pourya Arbab, Esmaeili, Habibollah, Keramati, Mohammad Reza |
| المصدر: |
Middle East Journal of Cancer; Jan2023, Vol. 14 Issue 1, p41-48, 8p |
| مصطلحات موضوعية: |
BIOLOGICAL models, REVERSE transcriptase polymerase chain reaction, RODENTS, B cells, CONFIDENCE intervals, CHRONIC myeloid leukemia, ANIMAL experimentation, CROSS-sectional method, MOLECULAR pathology, GENE expression, COMPARATIVE studies, HISTONES, DESCRIPTIVE statistics, GENES, TRANSCRIPTION factors |
| مصطلحات جغرافية: |
IRAN |
| مستخلص: |
Background: The B-cell-specific Moloney murine leukemia virus integration site1 (BMI-1) is one of the famous members of the Polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. Hence, it is believed to be necessary to further clarify the effects of the BMI-1 clinical. Method: This cross-sectional study was conducted on 70 acute myeloid leukemia (AML), 70 chronic myeloid leukemia (CML), and 20 healthy individuals, as the control group. We used real-time quantitative polymerase chain reaction in order to assess the BMI-1 level expression and its effect on prognosis in AML patients in the Molecular Pathology Research Center. Results: The results of the present work indicated that the BMI-1 overexpression was significantly higher in the AML and CML patients compared with that in the healthy controls (P < 0.001). Furthermore, a significant relationship was observed between the BMI-1 overexpression and poor prognosis in the AML patients (Hazard ratio=1.749, P < 0.001, 95% confidence interval = 1.31-2.32). Additionally, BMI-1 high was found in chronic and blastic phase in the CML patients (P < 0.001). Conclusion: We concluded that investigation of BMI-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
