Impact of chemotherapy-induced menopause in women of childbearing age with non-metastatic breast cancer – Preliminary results from the MENOCOR study
| العنوان: | Impact of chemotherapy-induced menopause in women of childbearing age with non-metastatic breast cancer – Preliminary results from the MENOCOR study |
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| المؤلفون: | Aude-Marie Savoye, Emilie Thivat, Angeline Ginzac, Marie-Ange Mouret-Reynier, Xavier Durando, Frédérique Penault-Llorca, Catherine Abrial, Olivier Collard, Fabrice Kwiatkowski, Joyce Dohou, Judith Passildas |
| المساهمون: | Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Institut de Cancérologie de la Loire Lucien Neuwirth, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institut Jean Godinot [Reims], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Mollecular Oncology Laboratory, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E) |
| المصدر: | Clinical Breast Cancer Clinical Breast Cancer, Elsevier, 2018, 19 (1), pp.e74-e84. ⟨10.1016/j.clbc.2018.10.003⟩ Clinical Breast Cancer, 2018, 19 (1), pp.e74-e84. ⟨10.1016/j.clbc.2018.10.003⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Cancer Research, medicine.medical_specialty, Adolescent, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Menstruation, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Quality of life, Internal medicine, Surveys and Questionnaires, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Prospective Studies, 10. No inequality, Ovarian reserve, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, business.industry, Middle Aged, Interim analysis, medicine.disease, Prognosis, humanities, Hormones, 3. Good health, Menopause, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Amenorrhea, Female, medicine.symptom, business, Follow-Up Studies |
| الوصف: | Background Young patients with breast cancer treated with chemotherapy can experience ovarian failure, which can lead to chemotherapy-induced menopause (CIM) impacting the quality of life (QoL). A prospective study was set out to evaluate the impact of CIM on QoL in women of childbearing age with non-metastatic breast cancer, and this article reports results of the interim analysis conducted to evaluate feasibility and to see preliminary results. Patients and Methods A total of 58 women (age, 18-46 years) with newly diagnosed breast cancer and treated with chemotherapy were eligible. QoL was assessed by self-administered questionnaires (Quality of Life Questionnaire-Core 30 [QLQ-C30], Quality of Life Questionnaire-Breast 23 [QLQ-BR23], and Kupperman index) and hormonal variations (anti-Mullerian hormone [AMH], follicle-stimulating hormone, and estradiol) were explored. We compared patients with ≥ 12 months amenorrhea (CIM) (n = 41) to patients with Results A good inclusion rate (approximately 4/month) and sufficient data enabled us to perform this analysis. QLQ-C30 failed to show any difference between CIM and non-CIM patients (P = .5). In contrast, at 6 months post-chemotherapy, CIM patients tended to have lower QoL as shown by QLQ-BR23 (P = .16) and more severe climacteric symptoms (P = .01). Regarding hormonal variations, AMH pre-treatment level was higher in non-CIM patients (P = .0032). We also noted that CIM patients were older (P = .00013), had shorter menstruation cycle (P = .082), and experienced faster amenorrhea (P = .088). Conclusions The study is technically feasible, and our preliminary results underline that age in association with pre-treatment AMH level could be helpful to predict ovarian function. QLQ-BR23 seemed to be stronger, more precise, and appropriate to evaluate QoL changes in patients with breast cancer than the QLQ-C30. |
| اللغة: | English |
| تدمد: | 1526-8209 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920f9286296bbcac325319408800b186Test https://hal.archives-ouvertes.fr/hal-01904507Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....920f9286296bbcac325319408800b186 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15268209 |
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