دورية أكاديمية
Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water
| العنوان: | Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water |
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| المؤلفون: | Marie-Ève Martineau-Dussault, Claire André, Véronique Daneault, Andrée-Ann Baril, Katia Gagnon, Hélène Blais, Dominique Petit, Jacques Y. Montplaisir, Dominique Lorrain, Célyne Bastien, Carol Hudon, Maxime Descoteaux, Arnaud Boré, Guillaume Theaud, Cynthia Thompson, Julie Legault, Guillermo E. Martinez Villar, Alexandre Lafrenière, Chantal Lafond, Danielle Gilbert, Julie Carrier, Nadia Gosselin |
| المصدر: | NeuroImage: Clinical, Vol 36, Iss , Pp 103235- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Sleep-disordered breathing, Entorhinal cortex, Hippocampus, Sex differences, Mild cognitive impairment, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer’s disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55–86 years (35 % women). We also investigated the impact of sex, age, cognitive status, and free-water fraction correction on these associations. Increased OSA severity was associated with larger hippocampal and entorhinal cortex volumes in women, but not in men. Greater OSA severity also correlated with increased hippocampal volumes in participants with amnestic mild cognitive impairment, but not in cognitively unimpaired participants, regardless of sex. Using free-water corrected volumes eliminated all significant associations with OSA severity. Therefore, the increase in medial temporal subregion volumes may possibly be due to edema. Whether these structural manifestations further progress to neuronal death in non-treated OSA patients should be investigated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S221315822200300XTest; https://doaj.org/toc/2213-1582Test |
| DOI: | 10.1016/j.nicl.2022.103235 |
| الوصول الحر: | https://doaj.org/article/9402f8178e3f42b68cfd33f2e3140053Test |
| رقم الانضمام: | edsdoj.9402f8178e3f42b68cfd33f2e3140053 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2022.103235 |