دورية أكاديمية
Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage:risk factors for presence of aneurysms and diagnostic yield of imaging
| العنوان: | Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage:risk factors for presence of aneurysms and diagnostic yield of imaging |
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| المؤلفون: | Bakker, Nicolaas A., Groen, Rob J. M., Foumani, Mahrouz, Uyttenboogaart, Maarten, Eshghi, Omid S., Metzemaekers, Joannes, Luijckx, Gert Jan, van Dijk, J. Marc C. |
| المصدر: | Bakker , N A , Groen , R J M , Foumani , M , Uyttenboogaart , M , Eshghi , O S , Metzemaekers , J , Luijckx , G J & van Dijk , J M C 2014 , ' Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage : risk factors for presence of aneurysms and diagnostic yield of imaging ' , Journal of Neurology, Neurosurgery and Psychiatry , vol. 85 , no. 8 , pp. 883-886 . https://doi.org/10.1136/jnnp-2013-305955Test |
| سنة النشر: | 2014 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | COMPUTED-TOMOGRAPHY, CEREBRAL-ANGIOGRAPHY, SCAN, METAANALYSIS |
| الوصف: | OBJECTIVE: Patients without a subarachnoid haemorrhage (SAH) on brain CT scan (CT-negative), but a lumbar puncture (LP)-proven SAH, are a challenging patient category. The optimal diagnostic approach is still a matter of debate. Also, there is little knowledge on the probability of finding an underlying vascular lesion. DESIGN: In this observational study, a consecutive cohort of 94 patients with CT-negative, LP-positive SAH was prospectively collected between 1998 and 2013. The yield of diagnostic modalities as well as patient outcome was studied. In addition, risk factors for the presence of a vascular lesion were analysed. RESULTS: In 40 patients (43%), an intracranial vascular abnormality was detected: 37 aneurysms and three arterial dissections. Female gender was significantly associated with detection of a vascular lesion. Time between ictus and diagnosis of SAH was not associated with the presence of vascular pathology. Overall, 99% of patients had a modified Rankin Score of 0-2 after a median follow-up of 72 months. The yield of additional digital subtraction angiography in patients with a negative CT angiography was zero. CONCLUSIONS: In this study, the chance of finding a vascular lesion in a patient with CT-negative, LP-positive SAH was 43%, underlining the need for an adequate diagnostic workup. In general, the patient outcome was favourable. Female gender was found to be predictive for detecting a vascular lesion. In contrast with previous reports, the interval between ictus and LP was not associated with the presence of an aneurysm. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/f4d0eecc-cc0f-46d5-a5c9-9ec2b754fe2aTest |
| DOI: | 10.1136/jnnp-2013-305955 |
| الإتاحة: | https://doi.org/10.1136/jnnp-2013-305955Test https://hdl.handle.net/11370/f4d0eecc-cc0f-46d5-a5c9-9ec2b754fe2aTest https://research.rug.nl/en/publications/f4d0eecc-cc0f-46d5-a5c9-9ec2b754fe2aTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.5722EDF9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/jnnp-2013-305955 |
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