Mechanism of intramolecular mixed anhydride formation as intermediates in the reactions of N-phosphorylamino-acids —An MNDO research
| العنوان: | Mechanism of intramolecular mixed anhydride formation as intermediates in the reactions of N-phosphorylamino-acids —An MNDO research |
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| المؤلفون: | Zhao Yu-fen, Zhong Rugang, Dai Qianhuan |
| المصدر: | Chinese Science Bulletin. 43:917-921 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Multidisciplinary, Chemistry, Concerted reaction, Mechanism (philosophy), Stereochemistry, Computational chemistry, Intramolecular force, MNDO, High activity |
| الوصف: | N-phosphoryl-α-amino acids can react to form esters, peptides, phosphoryl ester-exchanged products and phosphoryl group migration products under mild conditions, which are very important in researches on arohebiont. It has been proposed that intramolecular mixed carboxylic-phosphoric anhydrides (IMCPAs) might be the common intermediates of the reactions, which are difficult to be experimentally observed because of their high activity. In this note, it has been revealed, by means of MNDO, that the IMCPAs arc situated at the relatively minimal points of the potential surface and can form in a non-synchronous concerted reaction pathway that passes through a transition state with a hydrogen-bond-bridge structure. The results give a successful explanation to the structure and formation of IMCPAs and their ability to promote the various reactions mentioned above. |
| تدمد: | 1861-9541 1001-6538 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::c20d26816fd33a16a41845387e669a32Test https://doi.org/10.1007/bf02884612Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........c20d26816fd33a16a41845387e669a32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18619541 10016538 |
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