التفاصيل البيبلوغرافية
| العنوان: |
Tandem H/D Exchange-SET Reductive Deuteration Strategy for the Synthesis of α,β-Deuterated Amines Using D 2 O |
| المؤلفون: |
Shihui Luo (5179934), Chaoqun Weng (7553843), Zixuan Qin (11216637), Ke Li (106849), Tianxiao Zhao (8306922), Yuxuan Ding (3625970), Chen Ling (389353), Yuan Ma (189824), Jie An (543888) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Deuterated, reductive deuteration strategy, reductive deuteration, CH, CN, nitrile, tandem SmI 2, synthesis |
| الوصف: |
α,β-Deuterated amines are crucial for the development of deuterated drugs. We intend to introduce the novel tandem H/D exchange-single electron transfer (SET) reductive deuteration strategy with high pot- and reagent-economy by the synthesis of α,β-deuterated amine using nitrile as the precursor. The H/D exchange of the −CH 2 CN group was achieved by D 2 O/Et 3 N, which were also the required reagents in the tandem SmI 2 -mediated SET reductive deuteration of the α-deuterated nitrile. The potential application of this method was further showcased by the synthesis of bevantolol- d 4 . |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Tandem_H_D_Exchange-SET_Reductive_Deuteration_Strategy_for_the_Synthesis_of_-Deuterated_Amines_Using_D_sub_2_sub_O/15710721Test |
| DOI: |
10.1021/acs.joc.1c01276.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.joc.1c01276.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.9E33F078 |
| قاعدة البيانات: |
BASE |
