دورية أكاديمية
Estudo preliminar da toxicidade aguda e das atividades anti-edematogênica e anti-nociceptiva da 3,4-diidro-2-fenil-6-para-flúor-fenil-4-oxo-pirimidina-5-carbonitrila ; Preliminary studies on the acute toxicity, anti-edematogenic and analgesic activities of 3,4-dihydro-2-phenyl-6-para-fluorophenyl-4-oxo-pyrimidine-5-carbonitrile
| العنوان: | Estudo preliminar da toxicidade aguda e das atividades anti-edematogênica e anti-nociceptiva da 3,4-diidro-2-fenil-6-para-flúor-fenil-4-oxo-pirimidina-5-carbonitrila ; Preliminary studies on the acute toxicity, anti-edematogenic and analgesic activities of 3,4-dihydro-2-phenyl-6-para-fluorophenyl-4-oxo-pyrimidine-5-carbonitrile |
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| المؤلفون: | Anjos, Janaína V. dos, Mendonça Jr., Francisco J. B., Silva, Joao H. da Costa, Souza, Ivone A. de, Melo, Sebastiao J. |
| سنة النشر: | 2008 |
| المجموعة: | Universidad Nacional de La Plata (UNLP): SeDiCI (Servicio de Difusión de la Creación Intelectual) |
| مصطلحات موضوعية: | Farmacia, Farmacología, Agentes antiinflamatorios, Tests de toxicidad aguda, Compuestos heterocíclicos, dor, inflamação, pirimidinonas, toxicidade aguda, acute toxicity, inflammation, pain, pyrimidinones |
| الوصف: | A toxicidade aguda e as atividades anti-edematogênica e anti-nociceptiva da 3,4-diidro-2-fenil- 6-para-flúor-fenil-4-oxo-pirimidina-5-carbonitrila (PFP) foram avaliadas em roedores. A DL 50 da PFP, determinada por via intraperitoneal, foi estimada em 329,4 mg.kg -1 A PFP na dose de 32,9 mg.kg -1 . reduziu o edema de pata induzido por carragenina decorridas quatro e cinco horas (respectivamente, 57,1 ± 14,0 e 55,6 ± 19,4 %, p < 0,05) da aplicação da droga experimental. Na dose de 50 mg.kg -1 , a PFP reduziu o nú- mero de contorções abdominais em relação ao grupo não-tratado (inibição de 71,4 ( 8,5 %, p<0,05). Desta forma, conclui-se que PFP demonstrou ter baixa toxicidade e atividades anti-edematogênica e anti-nociceptiva em roedores, nos modelos de edema de pata e contorções abdominais, respectivamente. ; The acute toxicity, anti-edematogenic and analgesic activities of 3,4-dihydro-2-phenyl-6-para-fluorphenyl-4-oxo-pyrimidine-5-carbonitrile (PFP) were evaluated in rodents. The LD 50 , determined by intraperitoneal administration, was evaluated in 329.4 mg.kg -1 . The animals which received the experimental drug in the 32.9 mg.kg -1 dose showed reduction in the paw edema four and five hours after the administration (57.1 ± 14.0 and 55.6 ± 19.4 %, respectively, p < 0.05). In the 50 mg.kg -1 dose, the PFP reduced the number of contortions, when compared to the control group (71.4 ± 8.5 %, p < 0.05). In this way, it is possible to conclude that PFP has anti-edematogenic and analgesic activities through paw rat edema and number of abdominal cortortions models, respectively. ; Colegio de Farmacéuticos de la Provincia de Buenos Aires |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 339-344 |
| اللغة: | Portuguese |
| العلاقة: | http://sedici.unlp.edu.ar/handle/10915/7623Test; http://www.latamjpharm.org/trabajos/27/3/LAJOP_27_3_1_3_34Z844HHBD.pdfTest |
| الإتاحة: | http://sedici.unlp.edu.ar/handle/10915/7623Test http://www.latamjpharm.org/trabajos/27/3/LAJOP_27_3_1_3_34Z844HHBD.pdfTest |
| رقم الانضمام: | edsbas.F84AC3B8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |