التفاصيل البيبلوغرافية
| العنوان: |
Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder. |
| المؤلفون: |
Anshu, Kumari, Nair, Ajay Kumar, Srinath, Shoba, Laxmi, T. Rao |
| المصدر: |
Journal of Autism & Developmental Disorders; Nov2023, Vol. 53 Issue 11, p4390-4411, 22p, 1 Color Photograph, 1 Diagram, 7 Graphs |
| مصطلحات موضوعية: |
DIAGNOSIS of autism, NONPARAMETRIC statistics, STATISTICS, ANALYSIS of variance, ANIMAL experimentation, DEVELOPMENTAL disabilities, PSYCHOLOGY of movement, MANN Whitney U Test, PRENATAL exposure delayed effects, SEX distribution, RATS, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL models, DATA analysis, VALPROIC acid, EARLY medical intervention |
| مستخلص: |
Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
