Curcumin Alleviated Dextran Sulfate Sodium-Induced Colitis by Regulating M1/M2 Macrophage Polarization and TLRs Signaling Pathway
| العنوان: | Curcumin Alleviated Dextran Sulfate Sodium-Induced Colitis by Regulating M1/M2 Macrophage Polarization and TLRs Signaling Pathway |
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| المؤلفون: | Hai-Yan Wang, Youbao Zhong, Zeng-Ping Kang, Jian Long, Hai-Mei Zhao, Meng-Xue Wang, Duan-Yong Liu, Tiantian Wu |
| المصدر: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021) |
| بيانات النشر: | Hindawi, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Article Subject, Pharmacology, medicine.disease, M2 Macrophage, Ulcerative colitis, Proinflammatory cytokine, Other systems of medicine, chemistry.chemical_compound, TLR2, Complementary and alternative medicine, chemistry, medicine, TLR4, Curcumin, Colitis, CD163, RZ201-999, Research Article |
| الوصف: | Curcumin has shown good efficacy in mice with experimental colitis and in patients with ulcerative colitis, but the mechanism of action through the regulation of M1/M2 macrophage polarization has not been elaborated. The ulcerative colitis was modeled by dextran sulfate sodium; colitis mice were orally administrated with curcumin (10 mg/kg/day) or 5-ASA (300 mg/kg/day) for 14 consecutive days. After curcumin treatment, the body weight, colon weight and length, colonic weight index, and histopathological damage in colitis mice were effectively improved. The concentrations of proinflammatory cytokines IL-1β, IL-6, and CCL-2 in the colonic tissues of colitis mice decreased significantly, while anti-inflammatory cytokines IL-33 and IL-10 increased significantly. Importantly, macrophage activation was suppressed and M1/M2 macrophage polarization was regulated in colitis mice, and the percentage of CD11b+F4/80+ and CD11b+F4/80+TIM-1+ and CD11b+F4/80+iNOS+ decreased significantly and CD11b+F4/80+CD206+ and CD11b+F4/80+CD163+ increased significantly. Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-κBp65, p38MAPK, and AP-1 in colitis mice. Our study suggested that curcumin exerted therapeutic effects in colitis mice by regulating the balance of M1/M2 macrophage polarization and TLRs signaling pathway. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1741-4288 1741-427X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42352ddfa786d7feed90ba27430436c7Test http://europepmc.org/articles/PMC8463179Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42352ddfa786d7feed90ba27430436c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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