التفاصيل البيبلوغرافية
| العنوان: |
The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice. |
| المؤلفون: |
Nishihara, Michihide, Aoki, Hiroki, Ohno, Satoko, Furusho, Aya, Hirakata, Saki, Nishida, Norifumi, Ito, Sohei, Hayashi, Makiko, Imaizumi, Tsutomu, Fukumoto, Yoshihiro |
| المصدر: |
PLoS ONE; 10/05/2017, Vol. 12 Issue 10, p1-19, 19p |
| مصطلحات موضوعية: |
AORTIC aneurysms, INTERLEUKIN-6, MATRIX metalloproteinases, CYTOKINES, CELL motility |
| مستخلص: |
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear, evidence is accumulating to support a central role for inflammation. Inflammatory responses are coordinated by various soluble cytokines of which IL-6 is one of the major proinflammatory cytokines. In this study we examined the role of IL-6 in the pathogenesis of experimental AAA induced by a periaortic exposure to CaCl2 in mice. We now report that the administration of MR16-1, a neutralizing monoclonal antibody specific for the mouse IL-6 receptor, mildly suppressed the development of AAA. The inhibition of IL-6 signaling provoked by MR16-1 also resulted in a suppression of Stat3 activity. Conversely, no significant changes in either NFκB activity, Jnk activity or the expression of matrix metalloproteinases (Mmp) -2 and -9 were identified. Transcriptome analyses revealed that MR16-1-sensitive genes encode chemokines and their receptors, as well as factors that regulate vascular permeability and cell migration. Imaging cytometric analyses then consistently demonstrated reduced cellular infiltration for MR16-1-treated AAA. These results suggest that IL-6 plays an important but limited role in AAA pathogenesis, and primarily regulates cell migration and infiltration. These data would also suggest that IL-6 activity may play an important role in scenarios of continuous cellular infiltration, possibly including human AAA. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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