Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode
| العنوان: | Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode |
|---|---|
| المؤلفون: | Paulo Bettencourt, João Tiago Guimarães, Nuno Silva, Emília Patrício |
| المساهمون: | Instituto de Saúde Pública |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Microbiology (medical), medicine.medical_specialty, Immunoproteins, Cardiac biomarkers, Clinical Biochemistry, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal medicine, Biological variation, Natriuretic Peptide, Brain, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Research Articles, Aged, Retrospective Studies, Aged, 80 and over, Heart Failure, Innate immune system, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, Complement C4, Retrospective cohort study, Complement C3, Hematology, medicine.disease, Immunity, Innate, Eosinophils, Hospitalization, Acute Heart Failure, Medical Laboratory Technology, Innate Immunity Biomarkers, Echocardiography, Immune System, Heart failure, Reference values, Acute Disease, Immunology, Female, business, Biomarkers, After treatment |
| الوصف: | Background The involvement of the immune system in heart failure (HF) has been demonstrated. Evidence shows that innate immunity can have a role in the remodeling process and progression of HF. With previous studies showing the prognostic value of some innate immunity markers and their relevance in this condition, we aim to evaluate how these markers vary on hospitalization due to an acute episode of HF and at discharge. Methods About 154 patients admitted with acute HF were prospectively recruited. Patients were evaluated on admission and at discharge from the hospital. Patients with infection were separately analyzed. Innate immunity, inflammatory, and cardiac biomarkers were measured and were compared between groups and between admission and discharge and with reference values of biological variation. Results Median patients’ age was 78 years, and half of the patients were men. The median duration of hospitalization was 6 days. C3 and C4 protein levels significantly increased (P < 0.001) between admission and discharge, as well as eosinophils (P < 0.001) and BNP levels decreased (P < 0.001). Variation in all these variables was independent of infection and biological variation. Conclusion Our results show that innate immunity markers such as C3 and C4 increase after treatment for acute HF, supporting the hypothesis that they can be involved in the resolution of the acute episode. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8989b1bc8b772732afe8666ceee180Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b8989b1bc8b772732afe8666ceee180 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |