التفاصيل البيبلوغرافية
| العنوان: |
Prognostic significance of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in patients with oropharyngeal cancer treated with radiotherapy. |
| المؤلفون: |
Ng, Sweet Ping, Bahig, Houda, Jethanandani, Amit, Sturgis, Erich M., Johnson, Faye M., Elgohari, Baher, Gunn, G. Brandon, Ferrarotto, Renata, Phan, Jack, Rosenthal, David I., Frank, Steven J., Fuller, Clifton D., Garden, Adam S. |
| المصدر: |
British Journal of Cancer; 2021, Vol. 124 Issue 3, p628-633, 6p |
| مصطلحات موضوعية: |
PAPILLOMAVIRUSES, RESEARCH, ANALYSIS of variance, TIME, RESEARCH methodology, OROPHARYNGEAL cancer, PROGNOSIS, RETROSPECTIVE studies, REGRESSION analysis, MEDICAL cooperation, EVALUATION research, NEUTROPHILS, LYMPHOCYTES, COMPARATIVE studies, LEUKOCYTE count, KAPLAN-Meier estimator, RESEARCH funding, SQUAMOUS cell carcinoma, LYMPHOCYTE count |
| مستخلص: |
Background: This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer.Methods: Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphocytes. Survival rates were estimated using the Kaplan-Meier method. Univariable and multivariable analyses were conducted with linear and Cox regression methods. NLR was analysed posteriori and dichotomised on the discovered median.Results: Eight hundred and forty-eight patients were analysed. The median pre-RT NLR was 3. Patients with NLR of <3 had improved overall survival (OS) than those with NLR ≥ 3 (5-year OS 85 vs 74%, p < 0.0001). OS differences remained significant when stratified according to HPV status (HPV-positive p = 0.011; HPV-negative p = 0.003). Freedom from any recurrence (FFR), locoregional control (LRC) and freedom of distant recurrence (FDR) were better in those with NLR < 3. The negative impact of elevated pre-RT NLR on OS (HR = 1.64, p = 0.001), FFR (HR = 1.6, p = 0.006) and LRC (HR = 1.8, p = 0.005) remained significant on multivariable analysis.Conclusions: Pre-RT NLR is an independent prognostic factor in patients with oropharyngeal cancer regardless of HPV status. Patients with lower NLR had more favourable OS and disease control. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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