دورية أكاديمية
Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management
| العنوان: | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
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| المؤلفون: | Sánchez-Ramón, Silvia, Bermúdez, Arancha, González-Granado, Luis Ignacio, Rodríguez-Gallego, Carlos, Sastre, Ana, Soler Palacín, Pere |
| المساهمون: | Institut Català de la Salut, Sánchez-Ramón S Hospital Clínico San Carlos, Madrid, Spain. Bermúdez A Hospital Universitario Marqués de Valdecilla, Santander, Spain. González-Granado LI Hospital Universitario 12 Octubre, Madrid, Spain. Rodríguez-Gallego C Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Canary Islands, Spain. Sastre A Hospital Universitario La Paz, Madrid, Spain. Soler-Palacín P Hospital Universitari Vall d'Hebron, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Síndromes de deficiència immunitària - Diagnòstic, Sang - Càncer, Comorbiditat, DISEASES::Immune System Diseases::Immunologic Deficiency Syndromes, Other subheadings::Other subheadings::/diagnosis, DISEASES::Neoplasms::Neoplasms by Site::Hematologic Neoplasms, HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity, ENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia, Otros calificadores::Otros calificadores::/diagnóstico, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas, ATENCIÓN DE SALUD::calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::factores epidemiológicos::comorbilidad |
| الوصف: | Antibodies deficiency; Autoimmunity; Hematologic neoplasms ; Deficiència d'anticossos; Autoimmunitat; Neoplàsies hematològiques ; Deficiencia de anticuerpos; Autoimmunidad; Neoplasias hematológicas ; Background: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Haematologists and oncologists must therefore be aware of the association between blood disorders and cancer and ID, and be prepared to offer their patients appropriate treatment without delay. Our aim was to define the warning signs of primary and secondary IDs in paediatric and adult patients with oncohaematological manifestations. Methods: A multidisciplinary group of six experts (2 haematologists, 2 immunologists, and 2 paediatricians specializing in ID) conducted a literature review and prepared a document based on agreements reached an in-person meeting. An external group of 44 IDs specialists from all over Spain assessed the document and were consulted regarding their level of agreement. Results: This document identifies the haematological and extra-haematological diseases that should prompt a suspicion of PIDs in adults and children, in both primary care and haematology and oncology departments. Cytopenia and certain lymphoproliferative disorders are key diagnostic pointers. The diagnosis must be based on a detailed clinical history, physical exploration, complete blood count and standard laboratory tests. The immunological and haematological tests included in the diagnostic process will depend on the care level. Patients who are candidates for immunoglobulin replacement therapy must be carefully selected, and treatment should be offered as soon as possible to avoid the development of complications. Finally, this document ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| العلاقة: | Frontiers in Immunology;10; https://www.frontiersin.org/articles/10.3389/fimmu.2019.00586/fullTest; Sánchez-Ramón S, Bermúdez A, González-Granado LI, Rodríguez-Gallego C, Sastre A, Soler-Palacín P, et al. Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management. Front Immunol. 2019;10:586.; https://hdl.handle.net/11351/4143Test; WOS:000462540900001 |
| DOI: | 10.3389/fimmu.2019.00586 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2019.00586Test https://hdl.handle.net/11351/4143Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1CC9D2B2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2019.00586 |