دورية أكاديمية
Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial
| العنوان: | Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial |
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| المؤلفون: | Messier, Stephen P., Callahan, Leigh F., Beavers, Daniel P., Queen, Kate, Mihalko, Shannon L., Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., Quandt, Sara A., DeVita, Paul, Hunter, David J., Lyles, Mary F., Newman, Jovita, Hackney, Betsy, Jordan, Joanne M. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2017 |
| المجموعة: | Harvard University: DASH - Digital Access to Scholarship at Harvard |
| مصطلحات موضوعية: | Osteoarthritis, Knee pain, Clinical trial, Pragmatic, Community based research |
| الوصف: | Background: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown. Thus, the policy relevant and clinically important question is: Can we adapt this successful solution to a pervasive public health problem in real-world clinical and community settings? This study aims to develop a systematic, practical, cost-effective diet-induced weight loss and exercise intervention implemented in community settings and to determine its effectiveness in reducing pain and improving other clinical outcomes in persons with knee OA. Methods/Design This is a Phase III, pragmatic, assessor-blinded, randomized controlled trial. Participants will include 820 ambulatory, community-dwelling, overweight and obese (BMI ≥ 27 kg/m2) men and women aged ≥ 50 years who meet the American College of Rheumatology clinical criteria for knee OA. The primary aim is to determine whether a community-based 18-month diet-induced weight loss and exercise intervention based on social cognitive theory and implemented in three North Carolina counties with diverse residential (from urban to rural) and socioeconomic composition significantly decreases knee pain in overweight and obese adults with knee OA relative to a nutrition and health attention control group. Secondary aims will determine whether this intervention improves self-reported function, health-related quality of life, mobility, and is cost-effective. Discussion Many physicians who treat people with knee OA have no practical means to implement weight loss and exercise treatments as recommended by ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322619/pdfTest/; BMC Musculoskeletal Disorders; Messier, S. P., L. F. Callahan, D. P. Beavers, K. Queen, S. L. Mihalko, G. D. Miller, E. Losina, et al. 2017. “Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial.” BMC Musculoskeletal Disorders 18 (1): 91. doi:10.1186/s12891-017-1441-4. http://dx.doi.org/10.1186/s12891-017-1441-4Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072230Test |
| DOI: | 10.1186/s12891-017-1441-4 |
| الإتاحة: | https://doi.org/10.1186/s12891-017-1441-4Test http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072230Test |
| رقم الانضمام: | edsbas.BE9BFB95 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12891-017-1441-4 |
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