Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population
| العنوان: | Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population |
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| المؤلفون: | Birgit Strommenger, Kathleen R. Pritchett-Corning, Rainer G. Ulrich, Karsten Becker, Dania Richter, Werner Nicklas, Elisa Heuser, Dina Raafat, Franz-Rainer Matuschka, Bernd Walther, Sarah van Alen, Jens Jacob, Jens van den Brandt, Silva Holtfreter, René Ryll, Stefan Monecke, Jiri Pikula, Daniel M. Mrochen, Uta Westerhüs, Fawaz Al’Sholui |
| المصدر: | Toxins, Vol 12, Iss 2, p 80 (2020) Toxins Volume 12 Issue 2 |
| بيانات النشر: | Robert Koch-Institut, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Staphylococcus aureus, medicine.drug_class, Health, Toxicology and Mutagenesis, Population, Antibiotics, Virulence, lcsh:Medicine, habitat, Biology, Toxicology, medicine.disease_cause, Microbiology, 03 medical and health sciences, medicine, Colonization, rat, ddc:610, coagulation, education, 030304 developmental biology, staphylococcus aureus, 0303 health sciences, education.field_of_study, Molecular epidemiology, 030306 microbiology, clonal complex, lcsh:R, host adaptation, Methicillin-resistant Staphylococcus aureus, livestock, immune evasion cluster, epidemiology, Host adaptation, 610 Medizin und Gesundheit, laboratory |
| الوصف: | Rats are a reservoir of human- and livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). However, the composition of the natural S. aureus population in wild and laboratory rats is largely unknown. Here, 144 nasal S. aureus isolates from free-living wild rats, captive wild rats and laboratory rats were genotyped and profiled for antibiotic resistances and human-specific virulence genes. The nasal S. aureus carriage rate was higher among wild rats (23.4%) than laboratory rats (12.3%). Free-living wild rats were primarily colonized with isolates of clonal complex (CC) 49 and CC130 and maintained these strains even in husbandry. Moreover, upon livestock contact, CC398 isolates were acquired. In contrast, laboratory rats were colonized with many different S. aureus lineages&mdash many of which are commonly found in humans. Five captive wild rats were colonized with CC398-MRSA. Moreover, a single CC30-MRSA and two CC130-MRSA were detected in free-living or captive wild rats. Rat-derived S. aureus isolates rarely harbored the phage-carried immune evasion gene cluster or superantigen genes, suggesting long-term adaptation to their host. Taken together, our study revealed a natural S. aureus population in wild rats, as well as a colonization pressure on wild and laboratory rats by exposure to livestock- and human-associated S. aureus, respectively. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c927094c29f03811a892f09864472Test http://edoc.rki.de/176904/6532Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ac5c927094c29f03811a892f09864472 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |