دورية أكاديمية
Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa
| العنوان: | Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa |
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| المؤلفون: | Jia, Yamin, Guan, Qiunong, Jiang, Yong, Salh, Baljinder, Guo, Yuhai, Tu, Pengfei, Du, Caigan |
| المساهمون: | Du, CG (reprint author), Jack Bell Res Ctr, 2660 Oak St, Vancouver, BC V6H 3Z6, Canada., China Agr Univ, Coll Agr & Biotechnol, Beijing 100094, Peoples R China., Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC, Canada., Peking Univ, Sch Pharmaceut Sci, Modern Res Ctr Tradit Chinese Med, Beijing 100871, Peoples R China., Univ British Columbia, Dept Med, Div Gastroenterol, Vancouver, BC, Canada., Jack Bell Res Ctr, 2660 Oak St, Vancouver, BC V6H 3Z6, Canada. |
| المصدر: | SCI |
| بيانات النشر: | phytotherapy research |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | colitis, inflammatory bowel disease, echinacoside, TGF-beta, herba Cistanche, tissue repair, INFLAMMATORY-BOWEL-DISEASE, GROWTH-FACTOR, IN-VIVO, INTESTINAL INFLAMMATION, PARKINSONS-DISEASE, PHENOLIC-COMPOUNDS, CELL APOPTOSIS, KI-67 PROTEIN, MURINE MODEL, COLON-CANCER |
| الوصف: | Echinacoside (ECH) is a major bioactive phenyethanoids in medicinal herba Cistanche and has been reported to have antiinflammatory activity and beneficial effect on wound healing in many experimental studies. This study was to test the efficacy of ECH-enriched extract of Cistanche tubulosa in the treatment of dextran sulphate sodium (DSS)-induced colitis, a preclinical model of ulcerative colitis. Oral administration of ECH extract significantly suppresses the development of acute colitis, indicated by lowering disease activity index (p<0.0001, n=8) and preventing colonic damage (p=0.0336). Histological examinations showed that ECH extract treatment protected intestinal epithelium from inflammatory injury (p=0.0249) but had less effect on inflammatory cellular infiltration (p=0.1753). The beneficial effect of ECH extract treatment was associated with upregulation of transforming growth factor (TGF)-1 as well as with an increase in the number of Ki67(+) proliferating cells in diseased colons (p<0.0001). In cultured MODE-K cells, the addition of ECH extract enhanced in vitro wound healing that depended on TGF-1 expression. These data suggest that ECH extract possesses a greater efficacy in preventing DSS-induced colitis in mice, implying the potential of ECH or its derivatives for clinically treating inflammatory bowel disease. Copyright (c) 2013 John Wiley & Sons, Ltd. ; Chemistry, Medicinal ; Pharmacology & Pharmacy ; SCI(E) ; 1 ; ARTICLE ; caigan@mail.ubc.ca ; 1 ; 110-119 ; 28 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0951-418X 1099-1573 |
| العلاقة: | PHYTOTHERAPY RESEARCH.2014,28,(1),110-119.; 802914; http://hdl.handle.net/20.500.11897/218814Test; WOS:000329510400015 |
| DOI: | 10.1002/ptr.4967 |
| الإتاحة: | https://doi.org/20.500.11897/218814Test https://doi.org/10.1002/ptr.4967Test https://hdl.handle.net/20.500.11897/218814Test |
| رقم الانضمام: | edsbas.D2990649 |
| قاعدة البيانات: | BASE |
| تدمد: | 0951418X 10991573 |
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| DOI: | 10.1002/ptr.4967 |