التفاصيل البيبلوغرافية
| العنوان: |
Cooling: A facile, rapid, reagent-free and DNA-saving method for functionalization of gold nanorods with thiolated DNA. |
| المؤلفون: |
Chen, Jun1 (AUTHOR), Yan, Jianqin2 (AUTHOR), Sun, Qiqi1 (AUTHOR), Zhu, Wangwei1 (AUTHOR), He, Ziyun1 (AUTHOR), Pu, Yuji1 (AUTHOR), Li, Li1 (AUTHOR) Li_Li@scu.edu.cn, He, Bin1 (AUTHOR) bhe@scu.edu.cn |
| المصدر: |
Materials Letters. Feb2022:Part B, Vol. 308, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*DNA, *NANORODS, *COOLING, *GOLD nanoparticles, *HYDROGEN bonding |
| مستخلص: |
• Cooling is a facile and reagent-free method to modify DNA to gold nanorods (AuNRs) • DNA modification to AuNRs by cooling is a DNA saving method. • The DNA surface coverage density on AuNRs relies on the DNA/AuNR ratios and spacers. • Four degrees centigrade is a preferred temperature for optimal DNA modification. Conventional methods of functionalization of gold nanorods (AuNRs) with thiolated DNA include salt aging, pH-assisted method, ligand exchange, etc., most of which have limitations such as poor stability, operational difficulty, time consuming, strong cytotoxicity, and low predictability. Here, we demonstrate a facile, rapid, reagent-free and DNA saving method from freezing to cooling (−196 to 4 °C). No reagent is required for Au-S bond and more than 180 thiolated DNAs could be attached while feeding DNA/AuNR molar ratio is as low as 1000, within only several minutes. Cooling (4 °C) is a preferred modification temperature. Nanoscale ice might occur on the ternary interface of gold, water and DNA, while hydrogen bond is not strong enough to restrict DNA thermal motion. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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