Experiences are reported in the therapy of recurrent colics caused by ureteroliths. In 41 patients an initial treatment with indomethacin suppositories was performed which led to a removal of the colics in 37 patients. A comparative group of 46 patients was conventionally treated by means of an injection therapy of analgin/papaverin. In order to achieve painlessness, on a average 10 to 15 injections were necessary during the hospital treatment. The importance of the indomethacin therapy described lies in the possible self-application by the patient as well as in the avoidance of recurrent colics, frequent consultations of emergency physicians and hospitalisations.