التفاصيل البيبلوغرافية
| العنوان: |
Effectiveness of Aspirin on Major COPD Outcomes: A Prevalent New-User Design Observational Study |
| المؤلفون: |
Charles Khouri, Sophie Dell’Aniello, Pierre Ernst, Samy Suissa |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Medicine, Genetics, Pharmacology, Biotechnology, Cancer, Science Policy, Mortality, exacerbation, cohort study, propensity score, CPRD, pharacoepidemiology |
| الوصف: |
Observational studies that have reported an association between aspirin use in chronic obstructive pulmonary disease (COPD) with reductions in mortality and COPD exacerbations were shown to be affected by time-related biases. We assessed this association using a prevalent new-user study design that avoids these biases. We used the United Kingdom’s Clinical Practice Research Datalink (CPRD) to form a cohort of patients with COPD. Aspirin initiators were matched on time and propensity score with nonusers during 2002–2018. The outcomes were all-cause mortality and COPD exacerbation within a one-year follow-up. Hazard ratios (HR) and 95% confidence interval (CI) of each outcome associated with aspirin use compared to nonuse were estimated using an as-treated approach. The study cohort included 10,287 initiators of aspirin and 10,287 matched nonusers. The cumulative incidence of all-cause mortality at one year was 11.5% for aspirin users and 9.2% for nonusers. The HR of all-cause mortality associated with aspirin initiation was 1.22 (95% CI: 1.08–1.37), while for severe exacerbation it was 1.21 (95% CI 1.08–1.37), compared with nonuse. The HR of a first moderate or severe exacerbation with aspirin use was 0.90 (95% CI 0.85–0.95). These estimates did not vary by platelet count. This large population-based study, designed to emulate a trial, found aspirin use in patients with COPD associated with a higher risk of all-cause mortality and severe exacerbation, but a lower risk of moderate or severe exacerbation. Further research is warranted to assess this reduction in moderate or severe exacerbations, particularly in patients with cardiovascular risk factors. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Effectiveness_of_Aspirin_on_Major_COPD_Outcomes_A_Prevalent_New-User_Design_Observational_Study/25406968Test |
| DOI: |
10.6084/m9.figshare.25406968.v1 |
| الإتاحة: |
https://doi.org/10.6084/m9.figshare.25406968.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.B3E7B78E |
| قاعدة البيانات: |
BASE |
