Genetic and flow cytometry analysis of seronegative celiac disease: a cohort study
| العنوان: | Genetic and flow cytometry analysis of seronegative celiac disease: a cohort study |
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| المؤلفون: | Enrique Rodríguez de Santiago, Laura Crespo Pérez, Garbiñe Roy Ariño, Ana De Andrés Martín, Raquel Ríos León, Carlota García Hoz Jiménez, Agustín Albillos, Eugenia Sánchez Rodríguez, Ana Saiz González, Francisco León Prieto |
| المصدر: | Scandinavian Journal of Gastroenterology. 54:563-570 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Duodenum, Tissue transglutaminase, Biopsy, Disease, Gastroenterology, Autoimmune thyroiditis, Loss of heterozygosity, Lesion, Diet, Gluten-Free, Young Adult, 03 medical and health sciences, 0302 clinical medicine, GTP-Binding Proteins, HLA-DQ Antigens, Internal medicine, medicine, Humans, Protein Glutamine gamma Glutamyltransferase 2, Lymphocytes, Duodenal Diseases, Intestinal Mucosa, Aged, Autoantibodies, Retrospective Studies, Aged, 80 and over, Transglutaminases, biology, business.industry, Retrospective cohort study, Middle Aged, Flow Cytometry, medicine.disease, Immunoglobulin A, Celiac Disease, Logistic Models, 030220 oncology & carcinogenesis, biology.protein, Female, 030211 gastroenterology & hepatology, Atrophy, medicine.symptom, Antibody, business, Cohort study |
| الوصف: | Background: Seronegative celiac disease (CD) poses a diagnostic challenge.Aims: Characterize and identify differences between seronegative and seropositive CD.Patients and methods: Retrospective cohort study examining adult patients diagnosed with CD (1980–2017). Clinical, analytical, histological, genetic and immunophenotypic data were compiled. Seronegative CD was defined as a anti-tissue transglutaminase type 2 IgA and endomysial antibodies (EMA) negative and HLA-DQ2 and/or DQ8 positive, showing clinical signs of CD plus an abnormal duodenal biopsy, and responding to a gluten-free diet (GFD). Factors associated with seronegative CD were identified through binomial logistic regression.Results: Of 315 CD patients, 289 were seropositive (91.7%) and 26 seronegative (8.3%). Among the seronegative patients, higher prevalence was observed for autoimmune thyroiditis (26.9% vs. 9.7%, p = .016), HLA-DQ8 heterozygosity (23.1% vs. 2.5%, p ˂ .001) and Marsh I lesion (34.6% vs. 3.7%, p ˂ .001). The two group... |
| تدمد: | 1502-7708 0036-5521 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53da60486b9c9b0cd5ae07df5b6a2c71Test https://doi.org/10.1080/00365521.2019.1608466Test |
| رقم الانضمام: | edsair.doi.dedup.....53da60486b9c9b0cd5ae07df5b6a2c71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027708 00365521 |
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