التفاصيل البيبلوغرافية
| العنوان: |
Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies. |
| المؤلفون: |
Goodarzi, Golnoosh, Mozaffari, Hadis, Raeisi, Tahereh, Mehravar, Fatemeh, Razi, Bahman, Ghazi, Maryam Lafzi, Garousi, Nazila, Alizadeh, Shahab, Janmohammadi, Parisa |
| المصدر: |
BMC Cancer; 1/21/2022, Vol. 22 Issue 1, p1-14, 14p |
| مصطلحات موضوعية: |
COLORECTAL cancer, DISEASE risk factors, COHORT analysis, SCIENCE databases, WEB databases, OBESITY complications, OBESITY, RESEARCH, BODY weight, META-analysis, RESEARCH methodology, SYSTEMATIC reviews, EVALUATION research, METABOLIC disorders, RISK assessment, COMPARATIVE studies, ODDS ratio, BODY mass index, LONGITUDINAL method, PHENOTYPES, DISEASE complications |
| مستخلص: |
Background: The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status.Objective: This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk.Methods: The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes.Results: A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09-1.31) in MUHNW, 1.14 (95% CI = 1.06-1.22) in MHO, and 1.24 (95% CI = 1.19-1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants.Conclusions: The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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