Age-Related Changes in Nerve Growth Factor Receptor Immunoreactive Neurons in the Magnocellular Basal Forebrain System in Rat Brain – an Immunocytochemical and Morphometric Study
| العنوان: | Age-Related Changes in Nerve Growth Factor Receptor Immunoreactive Neurons in the Magnocellular Basal Forebrain System in Rat Brain – an Immunocytochemical and Morphometric Study |
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| المؤلفون: | Yuken Fukutani, K. Kobayashi, K. Miyazu, T. Aoki, F. Muramori, Nariyoshi Yamaguchi, M. Hayashi, M. Seki |
| المصدر: | Dementia and Geriatric Cognitive Disorders. 5:57-61 |
| بيانات النشر: | S. Karger AG, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, Cognitive Neuroscience, Receptors, Nerve Growth Factor, Biology, Nucleus basalis, Prosencephalon, Internal medicine, medicine, Neuropil, Animals, Tissue Distribution, Rats, Wistar, Cholinergic neuron, Neurons, Basal forebrain, Medial septal nucleus, Staining and Labeling, Immunohistochemistry, Diagonal band of Broca, Rats, Psychiatry and Mental health, Endocrinology, medicine.anatomical_structure, Nerve growth factor, nervous system, Female, Geriatrics and Gerontology, Nucleus |
| الوصف: | Morphometrical changes with aging in nerve growth factor receptor (NGFR) immunoreactive neurons in the basal forebrain were studied in juvenile and aged rat brains by means of NGFR immunohistochemistry. The nucleus basalis of Meynert (NBM) had cell loss and atrophy of NGFR immunoreactive neurons, and the horizontal nucleus of diagonal band of Broca (HNDB) showed only atrophy of these neurons. The medial septal nucleus and vertical nucleus of diagonal band of Broca had no significant change. Neuropil NGFR immunostaining was reduced in its intensity in the aged rats. As nerve growth factor is synthesized in the target areas and retrogradely transported to the nerve cell body within the basal forebrain and NGFR immunoreactive neurons are largely cholinergic ones, degeneration of NGFR-positive neurons in the basal forebrain may be related to a decreased cholinergic activity. The degeneration of the dendrites of NGFR-immunoreactive neurons were reported to be extensively found in the basal forebrain nuclei, in contrast, degeneration of the cell body of NGFR-immunoreactive neurons was confined to those in the NBM and HNDB in the present study. These findings suggest that atrophic changes in the dendrites precede those in the cell bodies of NGFR-immunoreactive neurons. |
| تدمد: | 1421-9824 1420-8008 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5cb1c812af1c1d032b5fcca0baa679Test https://doi.org/10.1159/000106698Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0a5cb1c812af1c1d032b5fcca0baa679 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219824 14208008 |
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