Smartphone‐based long‐term delayed memory performance is associated with the Preclinical Alzheimer's Cognitive Composite and CSF levels of β‐amyloid
| العنوان: | Smartphone‐based long‐term delayed memory performance is associated with the Preclinical Alzheimer's Cognitive Composite and CSF levels of β‐amyloid |
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| المؤلفون: | Fredrik Öhman, David Berron, Johan Skoog, Timothy Hadarsson Bodin, Silke Kern, Anna Zettergren, Kathryn V. Papp, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Michael Schöll |
| المصدر: | Alzheimer's and dementia 18(S2), (2022). doi:10.1002/alz.068015 Alzheimer's Association International Conference 2022 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Amyloid beta-Peptides, Epidemiology, Health Policy, Repression, Psychology, tau Proteins, Peptide Fragments, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cognition, Developmental Neuroscience, Alzheimer Disease, Humans, Neurogranin, Cognitive Dysfunction, ddc:610, Smartphone, Neurology (clinical), Geriatrics and Gerontology, Biomarkers, Aged, Retrospective Studies |
| الوصف: | Remote and unsupervised cognitive testing using smartphones may improve sensitivity to detect preclinical Alzheimer’s disease (AD). In particular, cognitive testing at-home enables the evaluation of the potentially more sensitive long-term delayed memory retrieval, which is commonly not feasible in a clinical setting.MethodHere, we investigated the association between remote and unsupervised smartphone-based cognitive assessments and in-clinic cognitive measurement in older participants (CDR = 0, MMSE = 29.2, age = 77). The sample (non-demented at age 70) was derived from the Swedish population-based Gothenburg H70 Birth Cohort Studies. In a subsample of participants, the retrospective correlation with cerebrospinal fluid (CSF) biomarkers analyzed at age 70 was further explored. To this point, 177 H70-participants have consented and were enrolled into the smartphone sub-study. They completed an “Object-in-Room Recall Test“ (ORR) remotely and unsupervised using own mobile devices, and the recall session was initiated 24 hours after the initial learning phase. Available previously assessed CSF measures included the Aβ42/Aβ40-ratio, t-tau, p-tau, neurofilament light (NFL), and neurogranin, available in-clinic cognitive tests included the Rey Auditory Verbal Learning Test (RAVLT), Semantic Fluency, Digit-Symbol-Coding, and Mini Mental State Examination. The above-mentioned cognitive tests were used to derive the Preclinical Alzheimer's Cognitive Composite (PACC5), a composite designed to be sensitive to cognitive change in preclinical AD. All associations were examined using Pearson correlation coefficient.ResultPreliminary analyses in a subset of participants yielded relatively strong positive correlations between PACC5 (R = .50, p |
| تدمد: | 1552-5279 1552-5260 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47222dd01a128fd5deb3c90e6a004112Test https://doi.org/10.1002/alz.068015Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....47222dd01a128fd5deb3c90e6a004112 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
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