التفاصيل البيبلوغرافية
| العنوان: |
Comparative toxicity and toxicokinetic studies of oxiracetam and (S)-oxiracetam in dogs. |
| المؤلفون: |
Liu, Tian-tian, Wei, Jin-feng, Wang, Ai-ping, Jin, Hong-tao, Guo, Xin-miao, Ye, Xiang-feng, Rong, Zu-yuan |
| المصدر: |
Xenobiotica; Sep2019, Vol. 49 Issue 9, p1054-1062, 9p |
| مصطلحات موضوعية: |
COGNITION disorders, DOGS |
| مستخلص: |
Oxiracetam (ORT) is known as a derivative of piracetam in the family of nootropics for treating memory impairment and cognition disorders. Given the chiral toxicological concerns surrounding ORT and the absence studies of (S)-ORT, the toxicity and toxicokinetics of (S)-ORT, and comparative toxicology of oxiracetam were systematically investigated in dogs following acute and 13-week repeated oral dosing. The animal toxicity mainly manifested as loose stools in both the acute and the 13-week studies. The no-observed-adverse-effect level is proposed to be 100 mg/kg. The 13-week toxicokinetics study indicated that, in the (S)-ORT group, the time to peak concentration was delayed, elimination half-life extended, and apparent volume of distribution increased compared with the ORT group. The clearance rate increased at low- and mid-doses, but decreased in the high-dose group and was accompanied by drug accumulation. Compared with the same dose of ORT, (S)-ORT had a lower clearance rate and longer elimination half-life. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
