التفاصيل البيبلوغرافية
| العنوان: |
Memory and Spatial Cognition in Breast Cancer Patients Undergoing Adjuvant Endocrine Therapy. |
| المؤلفون: |
Berndt, Ute, Leplow, Bernd, Schoenfeld, Robby, Lantzsch, Tilmann, Grosse, Regina, Thomssen, Christoph |
| المصدر: |
Breast Care; Aug2016, Vol. 11 Issue 4, p240-246, 7p, 2 Diagrams, 4 Charts |
| مصطلحات موضوعية: |
ESTROGEN replacement therapy, BREAST tumors, COGNITION, COMBINED modality therapy, MEMORY, SPACE perception, CROSS-sectional method, POSTMENOPAUSE, AROMATASE inhibitors |
| مستخلص: |
Introduction: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. Methods: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI ('SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21). Duration of the 2 endocrine monotherapy arms prior to the assessment ranged from 1 to 3 years. The 'SWITCH group' received 2-3 years TAM followed by at least 1 year and at most 3 years of AI. Memory and spatial cognition were investigated as planned comparisons. Investigations of processing speed, attention, executive function, visuoconstruction and self-perception of memory were exploratory. Results: With regard to general memory, AI patients performed significantly worse than the LT group (p = 0.013). Significant differences in verbal memory did not remain significant after p-value correction for multiple testing. We found no significant differences concerning spatial cognition between the groups. Conclusion: AI treatment alone significantly impairs general memory compared to the LT group. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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