دورية أكاديمية
Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders.
| العنوان: | Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. |
|---|---|
| المؤلفون: | Yubero, Montero R, Martín MA, Montoya J, Ribes A, Grazina M, Rodriguez Aguilera JC, Hargreaves IP, Navas P, Artuch R, CoQ deficiency study group, Jou C, Jimenez Mallebrera C, Nascimento A, Pérez Dueñas B, Ortez C, Ramos F, Colomer J, O'Callaghan M, Pineda M, García Cazorla A, Espinós C, Ruiz A, Macaya A, Marcé Grau A, Garcia Villoria J, Arias A, Emperador S, Ruiz Pesini E, Lopez Gallardo E, Neergheen V, Simões M, Diogo L, Blázquez A, González Quintana A, Delmiro A, Domínguez González C, Arenas J, García Silva MT, Martín E, Quijada P, Hernández Laín A, Morán M, Rivas Infante E, Ávila Polo R, Paradas Lópe C, Bautista Lorite J, Martínez Fernández EM, Cortés AB, Sánchez Cuesta A, Cascajo MV, Alcázar M, Brea Calvo G., TREVISSON, EVA, SALVIATI, LEONARDO |
| المساهمون: | Yubero, Montero, R, Martín, Ma, Montoya, J, Ribes, A, Grazina, M, Trevisson, Eva, Rodriguez Aguilera, Jc, Hargreaves, Ip, Salviati, Leonardo, Navas, P, Artuch, R, CoQ deficiency study, Group, Jou, C, Jimenez Mallebrera, C, Nascimento, A, Pérez Dueñas, B, Ortez C, Ramos F, Colomer, J, O'Callaghan, M, Pineda, M, García Cazorla, A, Espinós, C, Ruiz, A, Macaya, A, Marcé Grau, A, Garcia Villoria, J, Arias, A, Emperador, S, Ruiz Pesini, E, Lopez Gallardo, E, Neergheen, V, Simões, M, Diogo, L, Blázquez, A, González Quintana, A, Delmiro, A, Domínguez González, C, Arenas, J, García Silva, Mt, Martín, E, Quijada, P, Hernández Laín, A, Morán, M, Rivas Infante, E, Ávila Polo, R, Paradas Lópe, C, Bautista Lorite, J, Martínez Fernández, Em, Cortés, Ab, Sánchez Cuesta, A, Cascajo, Mv, Alcázar, M, Brea Calvo, G. |
| سنة النشر: | 2016 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Coenzyme Q10, mitochondrial disorders, oxidative phosphorylation, Coenzyme Q10 deficiency |
| الوصف: | We evaluated the coenzyme Q10 (CoQ) levels in patients who were diagnosed with mitochondrial oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders (n=72). Data from the 72 cases in this study revealed that 44.4% of patients showed low CoQ concentrations in either their skeletal muscle or skin fibroblasts. Our findings suggest that secondary CoQ deficiency is a common finding in OXPHOS and non-OXPHOS disorders. We hypothesize that cases of CoQ deficiency associated with OXPHOS defects could be an adaptive mechanism to maintain a balanced OXPHOS, although the mechanisms explaining these deficiencies and the pathophysiological role of secondary CoQ deficiency deserves further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27374853; info:eu-repo/semantics/altIdentifier/wos/WOS:000384037300007; volume:30; firstpage:51; lastpage:58; numberofpages:8; journal:MITOCHONDRION; http://hdl.handle.net/11577/3220334Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84978159513; https://www.ncbi.nlm.nih.gov/pubmed/27374853Test |
| الإتاحة: | http://hdl.handle.net/11577/3220334Test https://www.ncbi.nlm.nih.gov/pubmed/27374853Test |
| رقم الانضمام: | edsbas.1A1D6257 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |