Susceptibility trends including emergence of linezolid resistance among coagulase-negative staphylococci and meticillin-resistant Staphylococcus aureus from invasive infections
| العنوان: | Susceptibility trends including emergence of linezolid resistance among coagulase-negative staphylococci and meticillin-resistant Staphylococcus aureus from invasive infections |
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| المؤلفون: | Decousser, Jean-Winoc, Desroches, Marine, Bourgeois-Nicolaos, Nadège, Potier, Julien, Jehl, François, Lina, Gérard, Cattoir, Vincent, Vandenesch, François, Doucet-Populaire, Florence, Group, Microbs Study |
| المساهمون: | AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Henri Mondor [Créteil], Bactéries, Pathogènes et Santé (UBaPS), Faculté de Pharmacie, Université Paris-Sud - Paris 11 (UP11)-Université Paris-Sud - Paris 11 (UP11), Faculté de Médecine, CHU Strasbourg-Université Louis Pasteur - Strasbourg I, Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de Reference des Staphylocoques, Université de Lyon, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Novartis (France), CHU Henri Mondor, Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, 2015, 46 (6), pp.622-630. ⟨10.1016/j.ijantimicag.2015.07.022⟩ International Journal of Antimicrobial Agents, Elsevier, 2015, 46 (6), pp.622-630. ⟨10.1016/j.ijantimicag.2015.07.022⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Resistance, Drug Resistance, Drug resistance, Bloodstream, Levofloxacin, medicine.disease_cause, chemistry.chemical_compound, Methicillin, Staphylococcus epidermidis, Drug Resistance, Multiple, Bacterial, Pharmacology (medical), Prospective Studies, Staphylococci, biology, Bacterial, General Medicine, Staphylococcal Infections, 23S, Hospitals, 3. Good health, Anti-Bacterial Agents, RNA, Ribosomal, 23S, Infectious Diseases, Staphylococcus aureus, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.IMM]Life Sciences [q-bio]/Immunology, France, Osteoarticular, Coagulase, Rifampin, Multiple, Microbiology (medical), Methicillin-Resistant Staphylococcus aureus, Microbial Sensitivity Tests, Staphylococcal infections, Microbiology, Antibiotic resistance, Bacterial Proteins, Daptomycin, medicine, Humans, Matrix-Assisted Laser Desorption-Ionization, Ribosomal, Spectrometry, Linezolid, Mass, medicine.disease, biology.organism_classification, Methicillin-resistant Staphylococcus aureus, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, RNA, Gentamicins, Fusidic Acid |
| الوصف: | International audience; Multiresistance in staphylococci constitutes a major challenge for the antimicrobial chemotherapy of invasive infections such as bacteraemia or bone and joint infections (BJIs). A nationwide prospective study was performed to detect antimicrobial resistance trends among staphylococci causing invasive infections. Between October 2011 and February 2012, 367 meticillin-resistant Staphylococcus aureus (MRSA) and 695 coagulase-negative staphylococci (CoNS) were collected from 37 French hospitals, mainly from bacteraemia (59.9%) and osteoarticular infections (29.0%). Minimum inhibitory concentrations (MICs) were determined by broth microdilution, and specific screening and confirmation tests were performed to detect heterogeneous vancomycin-intermediate S. aureus (hVISA). Staphylococcal isolates exhibiting a linezolid MIC\textgreater4 mg/L were further characterised to determinate their clonal relationships and the mechanism of resistance. MRSA exhibited additional resistances, including levofloxacin (82% associated resistance), gentamicin (13.6%), fusidic acid (13.6%) and rifampicin (6.5%), compromising oral step-down therapy in BJIs. Only two hVISA strains (0.5%) were identified. Among the CoNS, mainly Staphylococcus epidermidis (506/695; 72.8%), resistance to first- and second-line agents was more common. Linezolid resistance was identified in 10 CoNS (1.4%). The most frequent linezolid resistance mechanism was the G2576T mutation in 23S rDNA (9/10). For the first time in France, the cfr gene was found in five related sequence type 2 (ST2) S. epidermidis from two different hospitals, in association with ribosomal RNA and L3 ribosomal protein mutations. These national data must be considered when selecting empirical treatment for invasive staphylococcal infections. Moreover, the emergence and spread of linezolid-resistant CoNS carrying the cfr gene is of concern. |
| اللغة: | English |
| تدمد: | 0924-8579 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b354078cfd74f9b3c12e28946dd3871Test https://hal.science/hal-01911214Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4b354078cfd74f9b3c12e28946dd3871 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09248579 |
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